Handle region peptide (HRP),rat
- Product Name
- Handle region peptide (HRP),rat
- CAS No.
- 749227-53-0
- Chemical Name
- Handle region peptide (HRP),rat
- Synonyms
- Handle region peptide, rat;Handle region peptide (HRP),rat;L-Valine, L-arginyl-L-isoleucyl-L-leucyl-L-leucyl-L-lysyl-L-lysyl-L-methionyl-L-prolyl-L-seryl-;(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-3-methylpentanamido]-4-methylpentanamido]-4-methylpentanamido]hexanamido]hexanamido]-4-(methylsulfanyl)butanoyl]pyrrolidin-2-yl]formamido}-3-hydroxypropanamido]-3-methylbutanoic acid
- CBNumber
- CB54713714
- Molecular Formula
- C54H101N15O12S
- Formula Weight
- 1184.54
- MOL File
- 749227-53-0.mol
Handle region peptide (HRP),rat Property
- Density
- 1.34±0.1 g/cm3(Predicted)
- pka
- 3.27±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- CS-0045189
- Product name
- Handleregionpeptide,rat
- Packaging
- 1mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-0045189
- Product name
- Handleregionpeptide,rat
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0045189
- Product name
- Handleregionpeptide,rat
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
Handle region peptide (HRP),rat Chemical Properties,Usage,Production
Uses
Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.
in vivo
Handle region peptide, rat (0.1 mg/kg) suppresses leukocyte adhesion in the endotoxin-induced uveitis (EIU) retina, and decreases the leukocyte counts in rats. Handle region peptide, rat (0.1 mg/kg) lowers the protein concentration in EIU rats induced by LPS, and reduces the mRNA expression and the protein levels of inflammatory mediators such as ICAM-1, CCL2/MCP-1, and IL-6 in rats[2].
References
[1] He M, et al. Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 2009 Mar 15;606(1-3):155-61. DOI:10.1016/j.ejphar.2008.12.050
[2] Satofuka S, et al. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2686-92. DOI:10.1167/iovs.05-1458
Handle region peptide (HRP),rat Preparation Products And Raw materials
Raw materials
Preparation Products
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