TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT

Product Name
TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT
CAS No.
94825-57-7
Chemical Name
TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT
Synonyms
(D-alanine2,D-leucine5)enkephalin;(D-ALA2, D-LEU5)-ENKEPHALIN ACETATE;TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT;[D-ALA2, D-LEU5]-ENKEPHALIN ACETATE SALT;[D-Ala2, D-Leu5]-Enkephalin acetate salt,DADLE;(2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
CBNumber
CB5472798
Molecular Formula
C31H43N5O9
Formula Weight
629.71
MOL File
94825-57-7.mol
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TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT Property

storage temp. 
−20°C
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E7131
Product name
[D-Ala2, D-Leu5]-Enkephalin acetate salt
Purity
≥95% (HPLC)
Packaging
1mg
Price
$36.3
Updated
2024/03/01
Sigma-Aldrich
Product number
E7131
Product name
[D-Ala2, D-Leu5]-Enkephalin acetate salt
Purity
≥95% (HPLC)
Packaging
5mg
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
E7131
Product name
[D-Ala2, D-Leu5]-Enkephalin acetate salt
Purity
≥95% (HPLC)
Packaging
25mg
Price
$400
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
PEP0004633
Product name
[D-ALA2,D-LEU5]-ENKEPHALIN ACETATE
Purity
95.00%
Packaging
1MG
Price
$632.81
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0004633
Product name
[D-ALA2,D-LEU5]-ENKEPHALIN ACETATE
Purity
95.00%
Packaging
5MG
Price
$714.53
Updated
2021/12/16
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TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT Chemical Properties,Usage,Production

Uses

[D-Ala2, D-Leu5]-Enkephalin or DADLE has been used for use in immunocomplex kinetic assay, to determine the activation of p70s6k by DADLE in the cell clones D2 and DOE and in non-transfected parental Rat-1 fibroblasts and to assess the analgesic effect of WIN55,212-2 in mice.

General Description

[D-Ala2, D-Leu5]-Enkephalin acetate salt, also called DADLE, is an analog of endogenous δ-opioid peptide encephalin, and is metabolically stable.

Biochem/physiol Actions

[D-Ala2, D-Leu5]-Enkephalin can induce hibernation in ground squirrels, during summers, when they do not normally hibernate. In multiorgan block preparation, it can prolong the survival time of organs such as, heart, lung, liver, spleen and kidney, up to 46hrs. It aids in tolerance development of myocardium to ischemia. It might have tissue protective role in central nervous system. It prevents and reverses methamphetamine (METH)-induced damage of dopaminergic terminals of brain. It prevents naltrexone-sensitive PC12 cell apoptosis in serum deprivation conditions. Thus, it might play an essential role in the survival of neurons and organs.

TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT Suppliers

China 3 Switzerland 1 United States 2 Global 6
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80

94825-57-7, TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALTRelated Search:

[LEU5]-ENKEPHALIN H-TYR-D-ALA-GLY-PHE-D-LEU-OH N-Acetyl-D-leucine GLY-GLY-D-LEU GLYCYL-D-LEUCINE TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT

  • [D-ALA2, D-LEU5]-ENKEPHALIN ACETATE SALT
  • TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT
  • (D-ALA2, D-LEU5)-ENKEPHALIN ACETATE
  • (D-alanine2,D-leucine5)enkephalin
  • [D-Ala2, D-Leu5]-Enkephalin acetate salt,DADLE
  • (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
  • 94825-57-7
  • C31H43N5O9
  • Enkephalins
  • Peptides
  • Opioid Peptides
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical