5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID
- Product Name
- 5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID
- CAS No.
- 337904-92-4
- Chemical Name
- 5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID
- Synonyms
- 5-((tert-Butoxycarbonyl);5-(BOC-AMINO)NICOTINIC ACID;N-BOC-3-AMINO-PYRIDINE-5-CABOXYLIC ACID;5-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID;5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC A;5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID;5-tert-Butoxycarbonylamino-pyridine-3-carboxylic acid ,97%;5-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-3-carboxylicaci;3-Pyridinecarboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-;5-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-3-carboxylic acid
- CBNumber
- CB5474237
- Molecular Formula
- C11H14N2O4
- Formula Weight
- 238.24
- MOL File
- 337904-92-4.mol
5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID Property
- Boiling point:
- 360.4±27.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.15±0.10(Predicted)
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 211663
- Product name
- 5-((tert-Butoxycarbonyl)amino)nicotinicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- CHM0012543
- Product name
- 5-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $885.31
- Updated
- 2021/12/16
- Product number
- 211663
- Product name
- 5-((tert-Butoxycarbonyl)amino)nicotinicacid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W5544
- Product name
- 5-((tert-Butoxycarbonyl)amino)nicotinicacid
- Packaging
- 25g
- Price
- $2368
- Updated
- 2021/12/16
- Product number
- CM178724
- Product name
- 5-((tert-butoxycarbonyl)amino)nicotinicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $163
- Updated
- 2021/12/16
5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Synthesis
100-26-5
337904-92-4
General procedure for the synthesis of 5-BOC-aminonicotinic acid from 2,5-pyridinedicarboxylic acid: (A) Preparation of 5-[(tert-butoxycarbonyl)amino]nicotinic acid: 2,5-pyridinedicarboxylic acid (5.00 g, 29.9 mmol) was suspended in tert-butanol (35 mL), and triethylamine (8.34 mL, 59.8 mmol) and diphenylphosphate azide ( 7.10 mL, 32.9 mmol), followed by heating the reaction mixture under reflux conditions for 3 hours. Upon completion of the reaction, it was cooled by an ice bath and the pH of the reaction mixture was adjusted to less than 10 by addition of 1N aqueous sodium hydroxide solution, followed by washing with ether. The reaction mixture was again cooled in an ice bath and the pH was adjusted with 1N aqueous sodium hydroxide solution to about 4. The precipitated solid was collected by filtration and washed sequentially with water and ether to give 5-BOC-aminonicotinic acid as a white powder (3.27 g, 45.9% yield).1H-NMR (DMSO-d6) δ: 1.49 (9H, s), 8.45 (1H, s ), 8.66 (1H, s), 8.75 (1H, s), 9.83 (1H, br).
References
[1] Patent: EP1227084, 2002, A1
5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID manufacturers
- Product
- 5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID 337904-92-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-30