(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide

Uses

Product Name: (2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide
CAS No.: 2101517-69-3
Chemical Name: (2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide
Synonyms: BL 918 NEW;BL-918 (BL918);(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide;Benzeneacetamide, α-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(2,4-difluorophenyl)-, (αR)-;inhibit,disease,BL-918,cytoprotective,BL 918,BL918,Autophagy,kinase,autophagic,Unc-51 like kinase,Orally,Parkinson’s,ULK,Inhibitor
CBNumber: CB54747731
Molecular Formula: C23H15F8N3OS
Formula Weight: 533.4369256
MOL File: 2101517-69-3.mol

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(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Property

Density: 1.508±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 250 mg/mL (468.66 mM)
form: A solid
pka: 11.13±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B595838
Product name: BL918
Packaging: 5mg
Price: $240
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0008598
Product name: BL-918
Purity: 95.00%
Packaging: 5MG
Price: $458.3
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BB165666
Product name: BL 918 NEW
Packaging: 50mg
Price: $542.5
Updated: 2021/12/16

AK Scientific

Product number: 1916EP
Product name: (2R)-2-[[3,5-Bis(trifluoromethyl)phenyl]carbamothioylamino]-N-(2,4-difluorophenyl)-2-phenylacetamide
Packaging: 50mg
Price: $782
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BB165666
Product name: BL 918 NEW
Packaging: 10mg
Price: $155
Updated: 2021/12/16

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(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Chemical Properties,Usage,Production

Uses

BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.

Uses

BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.

(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Suppliers

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2101517-69-3, (2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamideRelated Search:

(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide

BL-918 (BL918)

BL 918 NEW

inhibit,disease,BL-918,cytoprotective,BL 918,BL918,Autophagy,kinase,autophagic,Unc-51 like kinase,Orally,Parkinson’s,ULK,Inhibitor

Benzeneacetamide, α-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(2,4-difluorophenyl)-, (αR)-

2101517-69-3