9-Fluorenol
- Product Name
- 9-Fluorenol
- CAS No.
- 1689-64-1
- Chemical Name
- 9-Fluorenol
- Synonyms
- hydrafinil;9h-fluoren-9-ol;9-HYDROXYFLUORENE;uorenoL;Hydranafil;1689-64- 1;9-FLUORENOL;fluoren-9-ol;Hydroxyfluoren;9-Fluorenol>
- CBNumber
- CB5476145
- Molecular Formula
- C13H10O
- Formula Weight
- 182.22
- MOL File
- 1689-64-1.mol
9-Fluorenol Property
- Melting point:
- 153-154 °C(lit.)
- Boiling point:
- 275.62°C (rough estimate)
- Density
- 1.0368 (rough estimate)
- refractive index
- 1.5994 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 13.34±0.20(Predicted)
- form
- Crystalline Powder
- color
- Cream
- Water Solubility
- Insoluble in water.
- BRN
- 1869799
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 1689-64-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 9H-fluoren-9-ol(1689-64-1)
- EPA Substance Registry System
- 9-Hydroxyfluorene (1689-64-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36/37/39-27-26
- RIDADR
- UN 3077 9/PG III
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- Yes
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 29062990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H31204
- Product name
- 9-Hydroxyfluorene
- Purity
- 96%
- Packaging
- 5g
- Price
- $56.2
- Updated
- 2024/03/01
- Product number
- H31204
- Product name
- 9-Hydroxyfluorene
- Purity
- 96%
- Packaging
- 25g
- Price
- $101
- Updated
- 2024/03/01
- Product number
- F0229
- Product name
- 9-Fluorenol
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $74
- Updated
- 2024/03/01
- Product number
- F0229
- Product name
- 9-Fluorenol
- Purity
- >99.0%(GC)
- Packaging
- 250g
- Price
- $422
- Updated
- 2024/03/01
- Product number
- L01917
- Product name
- 9-Fluorenol, 98+%
- Packaging
- 25g
- Price
- $86.2
- Updated
- 2024/03/01
9-Fluorenol Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
9-Fluorenol is used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs.
Application
9-Fluorenol is a wake-promoting agent and is considered a next-generation anti-drowsiness drug. It is also a potential environmental carcinogen.
9-Fluorenol is a dopamine reuptake inhibitor with IC50 of 9 μM, and a major metabolite of a compound developed as a wakefulness-promoting agent.
Preparation
Synthesis of 9-Fluorenol: A 5-g sample of 9-fluorenone is dissolved in 30 mL of warm ethanol in a 100-mL beaker. To this solution is added, dropwise, 10 mL of a reducing reagent, freshly prepared, which consists of 200 mg sodium methoxide,10 mL methanol, and 0.4 g sodium borohydride.This solution is allowed to stand undisturbed for 10-20 min. A color change is observed as the reaction proceeds from the yellow 9-fluorenone to the white 9-fluorenol.The product is precipitated by the addition of 50 mL of water and neutralized with 0.1 M HCl, vacuum filtered, and washed with cold water to remove any residual inorganic salt formed by the excess of the sodium borohydride reagent and hydrochloric acid.The dried crude product is sufficiently pure for characterization by melting point, infrared spectra,and NMR.The crude product melting point is 153°C, with a product yield of 95-100%.
A Synthesis of 9-Fluorenol: Sodium Borohydride Reduction of 9-Fluorenone
Definition
ChEBI: 9-Fluorenol is a member of the class of hydroxyfluorenes that is 9H-fluorene substituted by a hydroxy group at position 9 (the non-aromatic carbon). It has a role as an animal metabolite. It is a member of hydroxyfluorenes and a secondary alcohol.
Synthesis Reference(s)
The Journal of Organic Chemistry, 57, p. 6313, 1992 DOI: 10.1021/jo00049a045
Tetrahedron Letters, 13, p. 343, 1972
Synthesis
9-Fluorenol is prepared by reacting 9-fluorenone with THF solution of phosphazene under the action of boron catalyst.Add
9-fluorenone (0.8 mmol), a 0.2 M THF solution of phosphazene (80 μL,
0.016 mmol) and a 0.0762 M THF solution of boron catalyst (420 μL, 0.032
mmol) to a scintillation vial with magnetic stir bar in a glove box.
Place the scintillation vial in a Parr reactor. Seal the reactor.
Pressurize the reactor with hydrogen gas. Heat reaction mixture at 75°C
(inside the reactor). Stir the reaction mixture (1000 rpm) for 20 hours
at 75°C. Cool the mixture to room temperature and vent the Parr reactor
to obtain 9-hydroxyfluoren. Analyze the reaction mixture by 1H NMR spectroscopy using CDCl3 as solvent.
9-Fluorenol Preparation Products And Raw materials
Raw materials
Preparation Products
9-Fluorenol Suppliers
- Tel
- 13861152845
- 987349505@qq.com
- Country
- China
- ProdList
- 113
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44689
- Advantage
- 61
- Tel
- 0393-0393-0393-8910800 18236056670
- Fax
- 0393-8912775
- info@huichengchem.com
- Country
- China
- ProdList
- 557
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18738
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 9387
- Advantage
- 52
- Tel
- +86-021-62885108 +8613917661608
- info@spring-chem.com
- Country
- China
- ProdList
- 2068
- Advantage
- 57
- Tel
- 0370-2785118 17550508557
- Fax
- QQ：3470079902
- 675141927@qq.com
- Country
- China
- ProdList
- 3203
- Advantage
- 55
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6134
- Advantage
- 55
- Tel
- 025-66099280 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19915
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9978
- Advantage
- 55
- Tel
- 0554-2106669
- Fax
- 0554-2666215
- sales1@kedichem.com
- Country
- China
- ProdList
- 4924
- Advantage
- 55
- Tel
- 15523000485
- xingcanyaoye@sina.com
- Country
- China
- ProdList
- 1686
- Advantage
- 58
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 400-026-1533/(021) 6478-0600
- Fax
- +86 (21) 6459-2060
- sales@bokachem.com
- Country
- China
- ProdList
- 876
- Advantage
- 58
- Tel
- 17501653715
- xingui2022@126.com
- Country
- China
- ProdList
- 10021
- Advantage
- 58
- Tel
- 0510-85629785 18051595327
- Fax
- 0510-85625359
- sales@hlsw-bio.com
- Country
- China
- ProdList
- 112
- Advantage
- 58
- Tel
- 027-59420981,18702770802
- Fax
- 027-83322098
- Country
- China
- ProdList
- 1975
- Advantage
- 50
- Tel
- 010-1234567 18521000990
- Fax
- 86-021-33275113
- sonyuanchemical@163.com
- Country
- China
- ProdList
- 6479
- Advantage
- 50
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9484
- Advantage
- 50
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 0371-67759225 13526468238
- Fax
- +86-37155919558
- sales@hqmat.com
- Country
- China
- ProdList
- 814
- Advantage
- 55
- Tel
- 15618758386 15618758386
- Fax
- QQ:3004479444
- sales3@myuchem.com
- Country
- China
- ProdList
- 2073
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 17687
- Advantage
- 55
- Tel
- 025-87193546 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 9021
- Advantage
- 60
- Tel
- 021-50908862，442785678，326799392 18721037013
- Fax
- 021-50908862
- siyansales@126.com
- Country
- China
- ProdList
- 9627
- Advantage
- 58
- Tel
- 0371-86658258
- Fax
- 0371-60996044
- info@coreychem.com
- Country
- China
- ProdList
- 10453
- Advantage
- 58
- Tel
- 0371-53778726 18003825608
- Fax
- QQ：2885354392
- liuxiaoyan@alfachem.cn
- Country
- China
- ProdList
- 1958
- Advantage
- 58
- Tel
- 021-52907766-8042
- Fax
- 021-52906523
- Country
- China
- ProdList
- 9941
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27313
- Advantage
- 60
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20806
- Advantage
- 60
- Tel
- 0371-55289822 18737195735
- Fax
- QQ：2370407954
- 2370407954@qq.com
- Country
- China
- ProdList
- 1998
- Advantage
- 55
- Tel
- 18221735425
- sales@xinpingchem.com
- Country
- China
- ProdList
- 9942
- Advantage
- 58
View Lastest Price from 9-Fluorenol manufacturers
- Product
- 9-Fluorenol 1689-64-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.0%min. HPLC
- Supply Ability
- 10000
- Release date
- 2024-09-22
- Product
- 9-FLUORENOL 1689-64-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-21
- Product
- 9-Hydroxyfluorene;9-FLUORENOL;Hydrafinil 1689-64-1
- Price
- US $5.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%+
- Supply Ability
- 100kgs
- Release date
- 2021-05-20