RITODRINE

Product Name: RITODRINE
CAS No.: 26652-09-5
Chemical Name: RITODRINE
Synonyms: Lavopa;Premar;RITODRINE;ritodrina;Formoterol-d;RITODRINE USP/EP/BP;Phenoxybenzamine hydrochl;Ritodrine Impurity 2 (Ritodrine);(1R,2S)-2-(4-Hydroxyphenethylamino)-1-(4-hydroxyphenyl)-1-propanol;4-[(1R,2S)-1-Hydroxy-2-[2-(4-hydroxyphenyl)ethylamino]propyl]phenol
CBNumber: CB5476882
Molecular Formula: C17H21NO3
Formula Weight: 287.35
MOL File: 26652-09-5.mol

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RITODRINE Property

Melting point:: 88-90 °C
Boiling point:: 512.3±45.0 °C(Predicted)
Density: 1.213±0.06 g/cm3(Predicted)
pka: pKa 9.0 (Uncertain)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: R2032-20B
Product name: Ritodrine
Packaging: 500ul
Price: $393
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009207
Product name: RITODRINE
Purity: 95.00%
Packaging: 250MG
Price: $627.24
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009207
Product name: RITODRINE
Purity: 95.00%
Packaging: 1G
Price: $857.66
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009207
Product name: RITODRINE
Purity: 95.00%
Packaging: 5G
Price: $1603.26
Updated: 2021/12/16

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RITODRINE Chemical Properties,Usage,Production

Description

Ritodrine, 4-hydroxy-α-[1-[(4′-hydroxyphenethyl)amino]ethyl]benzylic alcohol (11.1.19), differs slightly from epinephrine, and in the given example only one hydroxyl group has been added to the aromatic ring of the phenylethylamino region of classic sympathomimetics. The second major difference between the examined series is the replacement of the traditionally terminal iso-propyl or tert-butylamine region with a p-hydroxyphenylethylamine. Finally, the third difference is the presence of a methyl group at the α-atom of the phenylethylamine region of sympathomimetics, which makes it similar to isoetharine.

Uses

Relaxant (smooth muscle).

Uses

Ritodrine is a selective β2-adrenoreceptor stimulant, predominantly of the urino-genital system. It is used as a tocolytic agent for problems associated with premature miscarriages, and only in specialized medical facilities.

Definition

ChEBI: (1S,2R)-ritodrine is a 4-[2-[[1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol that has (1S,2R)-configuration. It is an enantiomer of a (1R,2S)-ritodrine.

General Description

Ritodrine is a selective β2-agonist that wasdeveloped specifically for use as a uterine relaxant. Its uterineinhibitory effects are more sustained than its effects onthe cardiovascular system, which are minimal comparedwith those caused by nonselective β-agonists. The cardiovasculareffects usually associated with its administrationare mild tachycardia and slight diastolic pressure decrease.Usually, it is administered initially by intravenous infusionto stop premature labor and subsequently it may be givenorally.

Clinical Use

Ritodrine is a selective β2-agonist that is used exclusively for relaxing uterine muscle and inhibiting the contractions of premature labor. Terbutaline, in addition to its use as a bronchodilator, also has been used for halting the contractions of premature labor.

Synthesis

Ritodrine is synthesized from 4-benzyloxypropiophenone, which undergoes bromination into 4-benzyloxy-|á-bromopropiophenone (11.1.17). This is reacted with 2-(4-benzyloxyphenyl)ethylamine, forming an intermediate product (11.1.18), which undergoes further debenzylation by hydrogen using a palladium catalyst, giving ritodrine (11.1.19) [24,25].

RITODRINE Preparation Products And Raw materials

Raw materials

Preparation Products

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RITODRINE Suppliers

China 32 Europe 2 Germany 1 India 2 South Korea 1 United Kingdom 2 United States 12 Global 52

ChemStrong Scientific Co.,Ltd

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View Lastest Price from RITODRINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: RITODRINE 26652-09-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

26652-09-5, RITODRINERelated Search:

Ephedrine RITODRINE HCL,RITODRINE HYDROCHLORIDE RITODRINE HCL RITODRINE HYDROCHLORIDE IMP. A (BP): TYRAMINE BEZAFIBRATE , RITODRINE RITODRINE

4-hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)-benzenemethano(

4-hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)benzenemethanol(r*

erythro-p-hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)benzylalcohol

RITODRINE

Benzenemethanol, 4-hydroxy-a-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, (aS)-rel- (9CI)

Benzenemethanol, 4-hydroxy-a-[1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, (R*,S*)-

Benzyl alcohol, p-hydroxy-a-[1-[(p-hydroxyphenethyl)amino]ethyl]-, erythro- (8CI)

(1R,2S)-1-(4-Hydroxyphenyl)-2-[(4-hydroxyphenethyl)amino]-1-propanol

(1R,2S)-2-(4-Hydroxyphenethylamino)-1-(4-hydroxyphenyl)-1-propanol

(1R,2S)-2-[(4-Hydroxyphenethyl)amino]-1-(4-hydroxyphenyl)-1-propanol

(αR)-4-Hydroxy-α-[(S)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]benzenemethanol

(αR)-p-Hydroxy-α-[(S)-1-[(p-hydroxyphenethyl)amino]ethyl]benzyl alcohol

Lavopa

Premar

4-[(1R,2S)-1-Hydroxy-2-[2-(4-hydroxyphenyl)ethylamino]propyl]phenol

p-hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)-benzylalcohoerythr

ritodrina

4-[2-[[(1S,2R)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol

Benzenemethanol, 4-hydroxy-α-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, (αS)-rel-

RITODRINE USP/EP/BP

Ritodrine Impurity 2 (Ritodrine)

Phenoxybenzamine hydrochl

Formoterol-d

26652-09-5