ChemicalBook > CAS DataBase List > 2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n

2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n

Product Name
2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n
CAS No.
73630-23-6
Chemical Name
2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n
Synonyms
QUIN 2;QUIN-2;Quin II (potassium);ium Salt Calbiochem;Quin-2 (potassium salt);QUIN 2, TetrapotaßQUIN 2, TETRAPOTASSIUM SALT;QUIN 2, Tetrapotassium Salt - CAS 73630-23-6 - Calbiochem;2-[[2-BIS(CARBOXYMETHYL)AMINO-5-METHYLPHENOXY]METHYL]-6-METHOXY-8-BIS(CARBOXYMETHYL)AMINOQUINOLINE, 4K;2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium salt
CBNumber
CB5479434
Molecular Formula
C26H28KN3O10
Formula Weight
581.62
MOL File
73630-23-6.mol
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2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n Property

Melting point:
>250℃
RTECS 
MB8303000
storage temp. 
2-8°C
solubility 
H2O: soluble10mg/mL
form 
powder
color 
Light yellow
Water Solubility 
Soluble in water at 10mg/ml
λmax
353 nm, 333 nm
Merck 
13,8130
BRN 
5374262
Biological Applications
Calcium indicator; cadmium indicator; iron indicator; lanthanum indicator; zinc indicator; identifying taste modulators
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
3-8-10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
551826
Product name
QUIN 2, Tetrapotassium Salt
Purity
Binding of Ca
Packaging
50mg
Price
$594
Updated
2024/03/01
Sigma-Aldrich
Product number
08520
Product name
Quin-2
Purity
suitable for fluorescence, ≥95% (HPLC)
Packaging
50mg
Price
$415
Updated
2024/03/01
Cayman Chemical
Product number
20421
Product name
Quin-2 (potassium salt)
Purity
≥90%
Packaging
5mg
Price
$178
Updated
2024/03/01
TRC
Product number
Q990005
Product name
QUIN 2, Tetrapotassium Salt
Packaging
100mg
Price
$310
Updated
2021/12/16
Usbiological
Product number
463357
Product name
QUIN 2, Tetrapotassium Salt
Packaging
50mg
Price
$509
Updated
2021/12/16
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2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n Chemical Properties,Usage,Production

Description

Quin-2 is a high-affinity fluorescent calcium indicator (Kd = 115 nM for calcium). It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH. High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells. Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation/emission maxima for quin-2 are 339 and 492 nm, respectively.

Uses

2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium salt can be used as a fluorescent highly selective Ca2+ indicator exhibiting fast uptake and release of Ca2+. Used as a calibration substance in the measurement of cytoplasmic free calcium.

Uses

QUIN 2, Tetrapotassium Salt is a useful fluorescing calcium indicator. It can also be used in biological study of practical aspects of measuring intracellular calcium signals with fluorescent indicators.

General Description

Binding of Ca2+ to QUIN 2 leads to a major shift in UV absorption spectrum and a twenty-fold enhancement in fluorescence quantum yield. TPEN (Cat. No. 616394) can be used in conjunction with QUIN 2 to reduce heavy-metal quenching of QUIN 2 fluorescence in cells. Spectral properties in the presence of low calcium concentrations (ex. 354 nm, em. 510 nm) differ from those during high calcium conditions (ex. 332 nm, em. 505 nm).

Biochem/physiol Actions

Primary TargetCalcium Probes

2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n Suppliers

China 33 Europe 2 Germany 1 Japan 1 Switzerland 4 United Kingdom 2 United States 6 Global 49
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73630-23-6, 2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,nRelated Search:

Zinquin Ethyl Ester MQAE Coelenterazine INDO 1-AM CALCEIN-AM Fura 2-AM FURA 2 PENTAPOTASSIUM SALT RHOD-2, AM Fluo 3-AM Fluo-3, pentaammonium salt TSQ ZINQUIN ETHYL ESTER QUIN 2-AM 8-Aminoquinoline 2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n QUIN 2 POTASSIUM HYDRATE QUIN 2

  • QUIN-2
  • QUIN 2, TETRAPOTASSIUM SALT
  • 2-[(2-AMINO-5-METHYLPHENOXY)METHYL]-6-METHOXY-8-AMINO-QUINOLINE-N,N,N',N'-TETRAACETIC ACID TETRAPOTASSIUM SALT
  • 2-[[2-BIS-(CARBOXYMETHYL)AMINO-5-METHYLPHENOXY]-METHYL]-6-METHOXY-8-BIS-(CARBOXYMETHYL)AMINOQUINOLINE TETRAPOTASSIUM SALT
  • 2-[[2-BIS(CARBOXYMETHYL)AMINO-5-METHYLPHENOXY]METHYL]-6-METHOXY-8-BIS(CARBOXYMETHYL)AMINOQUINOLINE, 4K
  • 2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium salt
  • 2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,Nμ,Nμ-tetraacetic acid tetrapotassium salt, 2-{[2-Bis-(carboxymethyl)amino-5-methylphenoxy]-methyl}-6-methoxy-8-bis-(carboxymethyl)aminoquinoline tetrapotassium salt
  • N-[2-[[8-[Bis(carboxymethyl)amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-N-(carboxymethyl)glycine tetrapotassium salt
  • QUIN 2
  • 2-{[2-Bis-(carboxymethyl)amino-5-methylphenoxy]-methyl}-6-methoxy-8-bis-(carboxymethyl)aminoquinoline tetrapotassium salt
  • Glycine, N-(2-((8-(bis(carboxymethyl)amino)-6-methoxy-2-quinolinyl)methoxy)-4-methylphenyl)-N-(carboxymethyl)-, tetrapotassium salt
  • Glycine,N-[2-[[8-[bis(carboxymethyl)amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-N-(carboxymethyl)<W
  • 2-[(2-amino-5-methylphenoxy)methyl]- 6-methoxy-8-aminoquinoline-n,n,n0,n0-tetraacetic acid Tetrapotassium Salt
  • Quin-2 (potassium salt)
  • QUIN 2, Tetrapotassium Salt - CAS 73630-23-6 - Calbiochem
  • 2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n,n-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n
  • ium Salt Calbiochem
  • QUIN 2, Tetrapota&szlig
  • Quin II (potassium)
  • 73630-23-6
  • C26H23K4N3O10
  • Biochemicals and Reagents
  • BioChemical
  • Fluorescent Probes, Labels, Particles and Stains
  • Detection
  • Quinoline