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BOS-172722

Product Name
BOS-172722
CAS No.
1578245-44-9
Chemical Name
BOS-172722
Synonyms
BOS-172722;BOS172722 ，S8911;BOS-172722 USP/EP/BP;BOS-172722, 10 mM in DMSO;autophosphorylation,Inhibitor,breast,cancer,BOS 172722,BOS172722,inhibit,BOS-172722,Monopolar spindle 1,Mps1;N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine;Pyrido[3,4-d]pyrimidine-2,8-diamine, N8-(2,2-dimethylpropyl)-N2-[2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl]-6-methyl-
CBNumber
CB54796638
Molecular Formula
C24H30N8O
Formula Weight
446.55
MOL File
1578245-44-9.mol
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BOS-172722 Property

Boiling point:
672.2±65.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:5.0(Max Conc. mg/mL);11.19(Max Conc. mM)
1M HCl:65.0(Max Conc. mg/mL);145.56(Max Conc. mM)
form 
Solid
pka
5.83±0.30(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0043580
Product name
BOS-172722
Purity
99.44%
Packaging
1mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-0043580
Product name
BOS-172722
Purity
99.44%
Packaging
5mg
Price
$590
Updated
2021/12/16
ChemScene
Product number
CS-0043580
Product name
BOS-172722
Purity
99.44%
Packaging
10mg
Price
$890
Updated
2021/12/16
ChemScene
Product number
CS-0043580
Product name
BOS-172722
Purity
99.44%
Packaging
25mg
Price
$1750
Updated
2021/12/16
ChemScene
Product number
CS-0043580
Product name
BOS-172722
Purity
99.44%
Packaging
50mg
Price
$2450
Updated
2021/12/16
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BOS-172722 Chemical Properties,Usage,Production

Uses

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer[1].

in vivo

BOS-172722 shows excellent PK in mouse, rat, and dog[1].
BOS-172722 (50 mg/kg) results in an increased suppression of MPS1 autophosphorylation at 6 and 24 h[1].

Animal Model:Dog[2].
Dosage:1 mg/kg (iv), 5 mg/kg (po) (Pharmacokinetic Analysis).
Administration:IV and PO.
Result:T1/2 = 12 h, Cmaxpo = 7770 nmol/L, AUCpo = 147035 h*nmol/L.

References

[1] ARYL SULFONOHYDRAZIDES. WO 2014037750 A1.

BOS-172722 Preparation Products And Raw materials

Raw materials

Preparation Products

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BOS-172722 Suppliers

China 44 United States 4 Global 48
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
Advantage
62
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Shanghai Benso Pharmaceutical Technology Co., Ltd.
Tel
15088289376
Email
248775804@qq.com
Country
China
ProdList
4901
Advantage
58
Shandong utilizing biological technology co., LTD
Tel
15966937598
Fax
3407640895 3071519937
Email
3407650895@qq.com
Country
China
ProdList
4215
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
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View Lastest Price from BOS-172722 manufacturers

Dideu Industries Group Limited
Product
BOS-172722 1578245-44-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-17

1578245-44-9, BOS-172722Related Search:


  • BOS-172722
  • N2-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine
  • Pyrido[3,4-d]pyrimidine-2,8-diamine, N8-(2,2-dimethylpropyl)-N2-[2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl]-6-methyl-
  • BOS-172722 USP/EP/BP
  • autophosphorylation,Inhibitor,breast,cancer,BOS 172722,BOS172722,inhibit,BOS-172722,Monopolar spindle 1,Mps1
  • BOS-172722, 10 mM in DMSO
  • BOS172722 ，S8911
  • 1578245-44-9