HDAC6-IN-1

Product Name: HDAC6-IN-1
CAS No.: 1815580-06-3
Chemical Name: HDAC6-IN-1
Synonyms: SKLB-23bb;HDAC6-IN-1;SKLB 23bb,Histone deacetylases,Inhibitor,HDAC,inhibit,SKLB23bb,SKLB-23bb;N-Hydroxy-4-(2-methoxy-5-(methyl(2-methylquinazolin-4-yl)amino)phenoxy)butanamide;Butanamide, N-hydroxy-4-[2-methoxy-5-[methyl(2-methyl-4-quinazolinyl)amino]phenoxy]-
CBNumber: CB54796658
Molecular Formula: C21H24N4O4
Formula Weight: 396.44
MOL File: 1815580-06-3.mol

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HDAC6-IN-1 Property

Density: 1.271±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: Soluble
form: A solid
pka: 9.32±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0014660
Product name: SKLB-23bb
Purity: 98.49%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0014660
Product name: SKLB-23bb
Purity: 98.49%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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HDAC6-IN-1 Chemical Properties,Usage,Production

Uses

SKLB-23bb is an orally bioavailable and selective HDAC6 inhibitor with IC50 of less than 100 nM in most cell lines tested; it can be used to disrupt microtubule activity.

in vitro

SKLB-23bb has toxic effects at low submolar levels in a range of solid and hematological tumor cell lines. Unlike reported selective HDAC6 inhibition, SKLB-23bb is more potent against solid tumors. SKLB-23bb selectively inhibits intracellular HDAC6, but its antitumor activity is independent of HDAC6. It can bind to the colchicine site of β-tubulin and is a microtubule polymerization inhibitor. SKLB-23bb also can arrest tumor cells in the G2-M phase and induce apoptosis.

in vivo

In a solid tumor model, oral administration of SKLB-23bb can effectively inhibit tumor growth. It has favorable pharmacokinetic properties and is orally active.

target

Target	Value
HDAC6 (Cell-based assay)	<100 nM

HDAC6-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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HDAC6-IN-1 Suppliers

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1815580-06-3, HDAC6-IN-1Related Search:

HDAC6-IN-1

SKLB-23bb

Butanamide, N-hydroxy-4-[2-methoxy-5-[methyl(2-methyl-4-quinazolinyl)amino]phenoxy]-

SKLB 23bb,Histone deacetylases,Inhibitor,HDAC,inhibit,SKLB23bb,SKLB-23bb

N-Hydroxy-4-(2-methoxy-5-(methyl(2-methylquinazolin-4-yl)amino)phenoxy)butanamide

1815580-06-3

12409072-27-9