Binding Mode
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Pemigatinib

Binding Mode
Product Name
Pemigatinib
CAS No.
1513857-77-6
Chemical Name
Pemigatinib
Synonyms
IBI-375;INCB54828;INCB-54828;INCB 54828;INCB-054828;Pemigatinib;Terbufos Impurity 14 (Ethion);INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic;3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one;3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
CBNumber
CB54796678
Molecular Formula
C24H27F2N5O4
Formula Weight
487.5
MOL File
1513857-77-6.mol
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Pemigatinib Property

Boiling point:
697.6±55.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:40.0(Max Conc. mg/mL);82.05(Max Conc. mM)
form 
A crystalline solid
pka
11.56±0.40(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0039499
Product name
Pemigatinib
Purity
99.88%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0039499
Product name
Pemigatinib
Purity
99.88%
Packaging
10mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-0039499
Product name
Pemigatinib
Purity
99.88%
Packaging
25mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0039499
Product name
Pemigatinib
Purity
99.88%
Packaging
50mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0039499
Product name
Pemigatinib
Purity
99.88%
Packaging
100mg
Price
$950
Updated
2021/12/16
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Pemigatinib Chemical Properties,Usage,Production

Binding Mode

Pemigatinib binds to the inactive conformation of FGFR1 with the activation loop adopting a DFG-in conformation (type I1/2 inhibitor). The pyrrolopyridine moiety forms two hydrogen bonds with the NH and the carbonyl of Ala564 in the hinge region (Figs. 3, 4). The difluoromethoxyphenyl ring, which is perpendicular relative to the tricyclic ring, fits the specificity pocket containing the gatekeeper residue Val561. One of the methoxy oxygen atoms hydrogen bonds to the backbone NH of Asp641. The terminal morpholine extends towards the solventfront region, and makes only minor contacts with the protein.

Uses

Pemigatinib is a potent inhibitor of FGFRs for the treatment of cholangiocarcinoma.

Indications

Pemigatinib is indicated for the treatment of previously treated adult patients with unresectable locally advanced or metastatic cholangiocarcinoma (CCA) who have been identified by an FDA-approved test for the presence of fibroblast growth factor receptor 2 (FGFR2) fusions or other rearrangements.

brand name

Pemazyre

General Description

Class: receptor tyrosine kinase; Treatment: metastatic cholangiocarcinoma; Other name: INCB054828; Elimination half-life = 15 h; Protein binding = 90.6%

target

Primary targets: Pan-FGFR

IC 50

FGFR1/2/3/4 IC 50 = 0.4, 0.5, 1, 30 nM

Pemigatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Pemigatinib Suppliers

Chongqing Chemieliva Pharmaceutical Co., Ltd.
Tel
023-67770219
Fax
+86 (23) 6777-0220
Email
jessica.hu@chemieliva.com
Country
China
ProdList
1440
Advantage
60
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 17702719238
Email
sales@sun-shinechem.com
Country
China
ProdList
960
Advantage
64
Chengdu aibike Pharmaceutical Technology Co., Ltd
Tel
18428121256
Email
wangxinlongzy@163.com
Country
China
ProdList
21
Advantage
58
Shenzhen Yaoyuan R&D Center Co., Ltd
Tel
13421666688 13421666688
Email
664261110@qq.com
Country
China
ProdList
410
Advantage
58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9461
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Gansu HaoTian Chemical Technology Co., Ltd.
Tel
0943-6900332 17789447501
Fax
0931-8238232
Email
zhuanxiajiang@haotianpharm.com
Country
China
ProdList
201
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4456
Advantage
55
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View Lastest Price from Pemigatinib manufacturers

Nanjing Fred Technology Co., Ltd
Product
Pemigatinib 1513857-77-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%, Single impurity<0.1
Supply Ability
1 ton
Release date
2023-12-29
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Pemigatinib 1513857-77-6
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-07-24
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Pemigatinib 1513857-77-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
50kg
Release date
2023-02-09

1513857-77-6, PemigatinibRelated Search:


  • Pemigatinib
  • 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • INCB-054828
  • 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-
  • IBI-375
  • 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic
  • INCB 54828
  • INCB54828
  • INCB-54828
  • 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • Terbufos Impurity 14 (Ethion)
  • 1513857-77-6
  • 1513857-77-7
  • C24H27F2N5O4
  • APIS