Binding Mode
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Pemigatinib

Binding Mode
Product Name
Pemigatinib
CAS No.
1513857-77-6
Chemical Name
Pemigatinib
Synonyms
IBI-375;INCB54828;INCB-54828;INCB 54828;INCB-054828;Pemigatinib;Terbufos Impurity 14 (Ethion);INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic;3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one;3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
CBNumber
CB54796678
Molecular Formula
C24H27F2N5O4
Formula Weight
487.5
MOL File
1513857-77-6.mol
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Pemigatinib Property

Boiling point:
697.6±55.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:40.0(Max Conc. mg/mL);82.05(Max Conc. mM)
form 
A crystalline solid
pka
11.56±0.40(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0039499
Product name
Pemigatinib
Purity
99.88%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0039499
Product name
Pemigatinib
Purity
99.88%
Packaging
10mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-0039499
Product name
Pemigatinib
Purity
99.88%
Packaging
25mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0039499
Product name
Pemigatinib
Purity
99.88%
Packaging
50mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0039499
Product name
Pemigatinib
Purity
99.88%
Packaging
100mg
Price
$950
Updated
2021/12/16
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Pemigatinib Chemical Properties,Usage,Production

Binding Mode

Pemigatinib binds to the inactive conformation of FGFR1 with the activation loop adopting a DFG-in conformation (type I1/2 inhibitor). The pyrrolopyridine moiety forms two hydrogen bonds with the NH and the carbonyl of Ala564 in the hinge region (Figs. 3, 4). The difluoromethoxyphenyl ring, which is perpendicular relative to the tricyclic ring, fits the specificity pocket containing the gatekeeper residue Val561. One of the methoxy oxygen atoms hydrogen bonds to the backbone NH of Asp641. The terminal morpholine extends towards the solventfront region, and makes only minor contacts with the protein.

Uses

Pemigatinib is a potent inhibitor of FGFRs for the treatment of cholangiocarcinoma.

Indications

Pemigatinib is indicated for the treatment of previously treated adult patients with unresectable locally advanced or metastatic cholangiocarcinoma (CCA) who have been identified by an FDA-approved test for the presence of fibroblast growth factor receptor 2 (FGFR2) fusions or other rearrangements.

brand name

Pemazyre

General Description

Class: receptor tyrosine kinase; Treatment: metastatic cholangiocarcinoma; Other name: INCB054828; Elimination half-life = 15 h; Protein binding = 90.6%

target

Primary targets: Pan-FGFR

IC 50

FGFR1/2/3/4 IC 50 = 0.4, 0.5, 1, 30 nM

Pemigatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Pemigatinib Suppliers

China 103 India 1 United States 5 Global 109
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
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View Lastest Price from Pemigatinib manufacturers

Nanjing Fred Technology Co., Ltd
Product
Pemigatinib 1513857-77-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%, Single impurity＜0.1
Supply Ability
1 ton
Release date
2023-12-29
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Pemigatinib 1513857-77-6
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-07-24
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Pemigatinib 1513857-77-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
50kg
Release date
2023-02-09

1513857-77-6, PemigatinibRelated Search:


  • Pemigatinib
  • 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • INCB-054828
  • 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-
  • IBI-375
  • 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic
  • INCB 54828
  • INCB54828
  • INCB-54828
  • 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
  • Terbufos Impurity 14 (Ethion)
  • 1513857-77-6
  • 1513857-77-7
  • C24H27F2N5O4
  • APIS