AZD 9272
- Product Name
- AZD 9272
- CAS No.
- 327056-26-8
- Chemical Name
- AZD 9272
- Synonyms
- AZD 9272;AZD 9272 (AZD9272;3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile;Benzonitrile, 3-fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-
- CBNumber
- CB54797024
- Molecular Formula
- C14H6F2N4O
- Formula Weight
- 284.22
- MOL File
- 327056-26-8.mol
AZD 9272 Property
- Boiling point:
- 446.3±55.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 50 mM
- form
- A solid
- pka
- -4.54±0.50(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 29717
- Product name
- AZD 9272
- Packaging
- 5mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 29717
- Product name
- AZD 9272
- Packaging
- 25mg
- Price
- $467
- Updated
- 2024/03/01
- Product number
- 29717
- Product name
- AZD 9272
- Packaging
- 10mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- 5613
- Product name
- AZD9272
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $164
- Updated
- 2021/12/16
- Product number
- 5613
- Product name
- AZD9272
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $690
- Updated
- 2021/12/16
AZD 9272 Chemical Properties,Usage,Production
Uses
AZD 9272 is a potent and selective nervous system penetrant mGlu5 antagonist showing psychoactive and psychomimetic effects.
in vivo
The clearance of AZD 9272 is low following a single intravenous dose at 3 μmol/kg and AZD 9272 is eliminated from plasma with terminal half-lives between 2 and 6 h. The terminal half-lives following oral dosing are similar to the half-lives following intravenous dosing. The volume of distribution at steady state is intermediate for AZD9272[1]. AZD9272 causes no cocaine-appropriate responding and causes a non-dose-dependent reduction in response rates at higher doses. AZD9272 at 2.84 mg/kg causes greater than 80% and typically more than 99% MTEP-appropriate responding up to 20 hours after dose, with a decline to approximately 20% at 24 hours after dose, yielding a t1/2 of 21.93 hours, and causes no systematic effects on response rates. The first time point at which AZD9272 causes >90% MTEP-appropriate responding is at 30 minutes after dose[2].
IC 50
mGluR5
storage
Store at RT
AZD 9272 Preparation Products And Raw materials
Raw materials
Preparation Products
AZD 9272 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77