DC1-SMe

Product Name: DC1-SMe
CAS No.: 501666-85-9
Chemical Name: DC1-SMe
Synonyms: DC1-SMe;DC1SMe,DC-1SMe;1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-
CBNumber: CB54797044
Molecular Formula: C35H30ClN5O4S2
Formula Weight: 684.23
MOL File: 501666-85-9.mol

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DC1-SMe Property

Boiling point:: 961.4±65.0 °C(Predicted)
Density: 1.522±0.06 g/cm3(Predicted)
pka: 9.47±0.40(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0067641
Product name: DC1SMe
Purity: >98.0%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0067641
Product name: DC1SMe
Purity: >98.0%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0067641
Product name: DC1SMe
Purity: >98.0%
Packaging: 25mg
Price: $1750
Updated: 2021/12/16

ChemScene

Product number: CS-0067641
Product name: DC1SMe
Purity: >98.0%
Packaging: 50mg
Price: $3150
Updated: 2021/12/16

ChemScene

Product number: CS-0067641
Product name: DC1SMe
Purity: >98.0%
Packaging: 100mg
Price: $5700
Updated: 2021/12/16

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DC1-SMe Chemical Properties,Usage,Production

Uses

DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

IC 50

Duocarmycins

References

[1] Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. DOI:10.1021/jm201284m

DC1-SMe Preparation Products And Raw materials

Raw materials

Preparation Products

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DC1-SMe Suppliers

China 15 United States 3 Global 18

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
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Shanghai Haoyuan Chemexpress Co., Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
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TargetMol Chemicals Inc.

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Shanghai Tachizaki Biomedical Research Center

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ChemExpress

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Guangzhou Weike Biotechnology Co., Ltd.

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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501666-85-9, DC1-SMeRelated Search:

DC1-SMe

1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-

DC1SMe,DC-1SMe

501666-85-9

C35H30ClN5O4S2