5-Azidomethyl-2'-beta-methyl uridine

Product Name: 5-Azidomethyl-2'-beta-methyl uridine
CAS No.: 2305415-72-7
Chemical Name: 5-Azidomethyl-2'-beta-methyl uridine
Synonyms: 5-Azidomethyl-2’-β-methyl uridine;5-Azidomethyl-2'-beta-methyl uridine;5-Azidomethyl-2’-beta-methyl ? uridine;5-(azidomethyl)-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
CBNumber: CB54842124
Molecular Formula: C11H15N5O6
Formula Weight: 313.27
MOL File: 2305415-72-7.mol

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5-Azidomethyl-2'-beta-methyl uridine Chemical Properties,Usage,Production

Uses

5-Azidomethyl-2’-beta-methyl uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5-Azidomethyl-2’-beta-methyl uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1] Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16(9):7980-93. DOI:10.3390/molecules16097980
[2] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

5-Azidomethyl-2'-beta-methyl uridine Preparation Products And Raw materials

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2305415-72-7, 5-Azidomethyl-2'-beta-methyl uridineRelated Search:

5-Azidomethyl-2'-beta-methyl uridine

5-Azidomethyl-2’-β-methyl uridine

5-Azidomethyl-2’-beta-methyl ? uridine

5-(azidomethyl)-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

2305415-72-7