Aumitin
- Product Name
- Aumitin
- CAS No.
- 946293-78-3
- Chemical Name
- Aumitin
- Synonyms
- Aumitin;Aumitin, 10 mM in DMSO;inhibit,Autophagy,Aumitin,Inhibitor;2-Chloro-N-(4-((4-methyl-6-(phenylamino)pyrimidin-2-yl)amino)phenyl)benzamide;Benzamide, 2-chloro-N-[4-[[4-methyl-6-(phenylamino)-2-pyrimidinyl]amino]phenyl]-
- CBNumber
- CB54844496
- Molecular Formula
- C24H20ClN5O
- Formula Weight
- 429.9
- MOL File
- 946293-78-3.mol
Aumitin Property
- Density
- 1.364±0.06 g/cm3(Predicted)
- pka
- 12.36±0.70(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- DC21865
- Product name
- Aumitin
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1600
- Updated
- 2021/12/16
- Product number
- DC21865
- Product name
- Aumitin
- Purity
- >98%
- Packaging
- 1g
- Price
- $3200
- Updated
- 2021/12/16
Aumitin Chemical Properties,Usage,Production
Uses
Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1].
Biological Activity
Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1].
References
[1]. Robke L, et al. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I. Chem Sci. 2018 Feb 26;9(11):3014-3022.
Aumitin Preparation Products And Raw materials
Raw materials
Preparation Products
Aumitin Suppliers
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