Bobcat339 (Bobcat 339)

Product Name: Bobcat339 (Bobcat 339)
CAS No.: 2280037-51-4
Chemical Name: Bobcat339 (Bobcat 339)
Synonyms: Bobcat399;Bobcat339 (Bobcat 339);Bobcat339, 10 mM in DMSO;1-([1,1'-Biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one;2(1H)-Pyrimidinone, 4-amino-1-[1,1'-biphenyl]-3-yl-5-chloro-;4-amino-1-{[1,1'-biphenyl]-3-yl}-5-chloro-1,2-dihydropyrimidin-2-one;enzyme,Inhibitor,Cytosine-based,TET,Bobcat 339,inhibit,Bobcat339,DNA Methyltransferase,DNA MTases,DNMTs,epigenetics,Bobcat-339,TET1,TET2
CBNumber: CB54844577
Molecular Formula: C16H12ClN3O
Formula Weight: 297.74
MOL File: 2280037-51-4.mol

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Bobcat339 (Bobcat 339) Property

Boiling point:: 489.0±55.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 1 mg/ml,DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:8): 0.11 mg/ml
form: A crystalline solid
pka: 2.42±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC22037
Product name: Bobcat339
Purity: >98%
Packaging: 100mg
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: DC22037
Product name: Bobcat339
Purity: >98%
Packaging: 250mg
Price: $900
Updated: 2021/12/16

DC Chemicals

Product number: DC22037
Product name: Bobcat339
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

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Bobcat339 (Bobcat 339) Chemical Properties,Usage,Production

Uses

Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].

Biological Activity

Bobcat339 is a cell penetrant, potent and selective inhibitor of TET1 and TET2 [Ten-eleven translocation methylcytosine dioxygenase (TET) 1 and 2] th at reduces content of 5-hydroxymethyl-cytosine (5hmC) in cultured neurons. Bobcat339 does not inhibit DNMT3a.

IC 50

TET1: 33 μM (IC₅₀); TET2: 73 μM (IC₅₀)

storage

Store at -20°C

References

[1] Chua GNL, et, al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31; 10(2): 180-185. DOI:10.1021/acsmedchemlett.8b00474
[2] Weirath NA, et al. Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper(II). ACS Med Chem Lett. 2022 Apr 21;13(5):792-798. DOI:10.1021/acsmedchemlett.1c00677

Bobcat339 (Bobcat 339) Preparation Products And Raw materials

Raw materials

Preparation Products

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Bobcat339 (Bobcat 339) Suppliers

China 47 United States 5 Global 52

Shanghai Lollane Biological Technology Co.,Ltd.

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View Lastest Price from Bobcat339 (Bobcat 339) manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Bobcat 339 2280037-51-4
Price: US $3.44/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Bobcat 339 2280037-51-4
Price: US $3.44/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2022-04-01

2280037-51-4, Bobcat339 (Bobcat 339)Related Search:

Bobcat339 (Bobcat 339)

Bobcat399

2(1H)-Pyrimidinone, 4-amino-1-[1,1'-biphenyl]-3-yl-5-chloro-

1-([1,1'-Biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one

enzyme,Inhibitor,Cytosine-based,TET,Bobcat 339,inhibit,Bobcat339,DNA Methyltransferase,DNA MTases,DNMTs,epigenetics,Bobcat-339,TET1,TET2

4-amino-1-{[1,1'-biphenyl]-3-yl}-5-chloro-1,2-dihydropyrimidin-2-one

Bobcat339, 10 mM in DMSO

2280037-51-4