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CU-3 (DGKα inhibitor CU-3)

Product Name
CU-3 (DGKα inhibitor CU-3)
CAS No.
1815598-71-0
Chemical Name
CU-3 (DGKα inhibitor CU-3)
Synonyms
2E)-CU-3;(5Z,2E)-CU-3;DGKα inhibitor CU-3;(5Z,2E)CU3,(5Z,2E) CU 3;CU-3 (DGKα inhibitor CU-3);CU-3 (DGKα inhibitor CU-3);N-((Z)-5-((E)-3-(Furan-2-yl)allylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzenesulfonamide;5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl)amino]2-thioxo-1,3-thiazolidin-4-one;N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-benzenesulfonamide;Benzenesulfonamide, N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-
CBNumber
CB54844678
Molecular Formula
C16H12N2O4S3
Formula Weight
392.47
MOL File
1815598-71-0.mol
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CU-3 (DGKα inhibitor CU-3) Property

Boiling point:
561.8±60.0 °C(Predicted)
Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 20 mg/mL (50.96 mM; ultrasonic and warming and heat to 60°C)
pka
4.72±0.20(Predicted)
form 
A solid
color 
Yellow to brown
Water Solubility 
Water: < 0.1 mg/mL (insoluble)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC20952
Product name
CU-3
Purity
>98%
Packaging
100mg
Price
$600
Updated
2021/12/16
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CU-3 (DGKα inhibitor CU-3) Chemical Properties,Usage,Production

Uses

(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].

References

[1] Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79. DOI:10.1194/jlr.M062794

CU-3 (DGKα inhibitor CU-3) Preparation Products And Raw materials

Raw materials

Preparation Products

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CU-3 (DGKα inhibitor CU-3) Suppliers

China 24 United States 8 Global 32
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Fax
021-65675885
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info@efebio.com
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China
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
Fax
022-23754520
Email
klq@cw-bio.com
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 18101056239
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3193328036@qq.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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010-60605840
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psaitong@jm-bio.com
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China
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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1815598-71-0, CU-3 (DGKα inhibitor CU-3)Related Search:


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  • DGKα inhibitor CU-3
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  • 2E)-CU-3
  • (5Z,2E)CU3,(5Z,2E) CU 3
  • 5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl)amino]2-thioxo-1,3-thiazolidin-4-one
  • N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-benzenesulfonamide
  • CU-3 (DGKα inhibitor CU-3)
  • N-((Z)-5-((E)-3-(Furan-2-yl)allylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzenesulfonamide
  • 1815598-71-0