ChemicalBook > CAS DataBase List > CU-3
(DGKα inhibitor CU-3)
CU-3 (DGKα inhibitor CU-3)
- Product Name
- CU-3 (DGKα inhibitor CU-3)
- CAS No.
- 1815598-71-0
- Chemical Name
- CU-3 (DGKα inhibitor CU-3)
- Synonyms
- 2E)-CU-3;(5Z,2E)-CU-3;DGKα inhibitor CU-3;(5Z,2E)CU3,(5Z,2E) CU 3;CU-3 (DGKα inhibitor CU-3);CU-3 (DGKα inhibitor CU-3);N-((Z)-5-((E)-3-(Furan-2-yl)allylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzenesulfonamide;5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl)amino]2-thioxo-1,3-thiazolidin-4-one;N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-benzenesulfonamide;Benzenesulfonamide, N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-
- CBNumber
- CB54844678
- Molecular Formula
- C16H12N2O4S3
- Formula Weight
- 392.47
- MOL File
- 1815598-71-0.mol
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CU-3 (DGKα inhibitor CU-3) Property
- Boiling point:
- 561.8±60.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 20 mg/mL (50.96 mM; ultrasonic and warming and heat to 60°C)
- pka
- 4.72±0.20(Predicted)
- form
- A solid
- color
- Yellow to brown
- Water Solubility
- Water: < 0.1 mg/mL (insoluble)
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- DC20952
- Product name
- CU-3
- Purity
- >98%
- Packaging
- 100mg
- Price
- $600
- Updated
- 2021/12/16
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CU-3 (DGKα inhibitor CU-3) Chemical Properties,Usage,Production
Uses
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
References
[1] Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79. DOI:10.1194/jlr.M062794
CU-3 (DGKα inhibitor CU-3) Preparation Products And Raw materials
Raw materials
Preparation Products
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