Linzagolix

Product Name: Linzagolix
CAS No.: 935283-04-8
Chemical Name: Linzagolix
Synonyms: OBE2109;RMA-895;OBE 2109;OBE-2109;Linzagolix;Linzagolix CAS;Zavegepant Impurity 55;Linzagolix, 10 mM in DMSO;3-{5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl}-2,4-dioxo-1H,2H,3H,4H-thieno[3,4-d]pyrimidine-5-carboxylic acid;3-(5-((2,3-difluoro-6-methoxybenzyl)oxy)-2-fluoro-4-methoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4-d]pyrimidine-5-carboxylic acid
CBNumber: CB54844986
Molecular Formula: C22H15F3N2O7S
Formula Weight: 508.42
MOL File: 935283-04-8.mol

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Linzagolix Property

storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (245.86 mM; Need ultrasonic)
form: Solid
color: White to light brown
InChIKey: BMAAMIIYNNPHAB-UHFFFAOYSA-N
SMILES: C1(=O)N(C2=CC(OCC3=C(OC)C=CC(F)=C3F)=C(OC)C=C2F)C(=O)C2=C(C(O)=O)SC=C2N1

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Hazard and Precautionary Statements (GHS)

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Linzagolix Chemical Properties,Usage,Production

Uses

Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research[1][2][3].

in vivo

Linzagolix (50 mg/kg) reduces cyst volume in a rat model of endometriosis^[1].
Lindagolix reduces serum luteinizing hormone and testosterone levels in male rats and dogs with normal or BPH models^[2].

Animal Model:	Endometriosis model rat^[1]
Dosage:	50 mg/kg
Administration:
Result:	Reduced cyst volume.

References

[1] Motohiro Tezuka, et al. Suppressive effects of linzagolix, a novel non-peptide antagonist of gonadotropin-releasing hormone receptors, in experimental endometriosis model rats. Clin Exp Pharmacol Physiol. 2023 Jul;50(7):610-617. DOI:10.1111/1440-1681.13778
[2] Motohiro Tezuka, et al. Suppression of hypothalamic-pituitary-gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models. Clin Exp Pharmacol Physiol. 2023 Nov;50(11):914-923. DOI:10.1111/1440-1681.13817
[3] Susan Dababou, et al. Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas. Expert Opin Investig Drugs. 2021 Sep;30(9):903-911. DOI:10.1080/13543784.2021.1957830

Linzagolix Preparation Products And Raw materials

Raw materials

Preparation Products

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Linzagolix Suppliers

China 68 India 1 United States 1 Global 70

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 18857119830
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Jiangxi Kaixin Biomedical Co., Ltd.

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Chunchuang (Wuhan) Technology Co., Ltd

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Shanghai Neff Biotechnology Co., LTD

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Hubei wei shi reagent group ltd., company

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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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Nanjing Chemlin Chemical Co., Ltd

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Bide Pharmatech Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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View Lastest Price from Linzagolix manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Linzagolix 935283-04-8
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-06-05

Moxin Chemicals

Product: Linzagolix 935283-04-8
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98
Supply Ability: 10000000
Release date: 2025-02-17

shandong perfect biotechnology co.ltd

Product: Linzagolix 935283-04-8
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 100kg
Release date: 2023-08-14

935283-04-8, LinzagolixRelated Search:

Linzagolix

Thieno[3,4-d]pyrimidine-5-carboxylic acid, 3-[5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl]-1,2,3,4-tetrahydro-2,4-dioxo-

OBE 2109

OBE2109

OBE-2109

KLH 2109,endometriosis,KLH-2109,GnRH Receptor,Gonadotropin releasing hormone receptor,inhibit,uterine fibroids,KLH2109,Linzagolix,GNRHR,adenomyosis,OBE 2109,Inhibitor,OBE-2109,OBE2109

3-[5-[(2,3-Difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl]-1,2,3,4-tetrahydro-2,4-dioxothieno[3,4-d]pyrimidine-5-carboxylic acid

3-(5-((2,3-difluoro-6-methoxybenzyl)oxy)-2-fluoro-4-methoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4-d]pyrimidine-5-carboxylic acid

Linzagolix CAS

Zavegepant Impurity 55

3-{5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl}-2,4-dioxo-1H,2H,3H,4H-thieno[3,4-d]pyrimidine-5-carboxylic acid

Linzagolix, 10 mM in DMSO

RMA-895

935283-04-8

C22H15F3N2O7S