PDGFRα kinase inhibitor 1

Product Name: PDGFRα kinase inhibitor 1
CAS No.: 2209053-93-8
Chemical Name: PDGFRα kinase inhibitor 1
Synonyms: PDGFRα kinase inhibitor 1;PDGFRα kinase inhibitor 1;3-Pyridinecarboxamide, N-[2-(dimethylamino)ethyl]-N-[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]-
CBNumber: CB54845039
Molecular Formula: C34H34N8O2
Formula Weight: 586.69
MOL File: 2209053-93-8.mol

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PDGFRα kinase inhibitor 1 Property

Density: 1.271±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 260 mg/mL (443.16 mM; Need ultrasonic)
pka: 13.06±0.70(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0042281
Product name: PDGFRαkinaseinhibitor1
Purity: 99.90%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0042281
Product name: PDGFRαkinaseinhibitor1
Purity: 99.90%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0042281
Product name: PDGFRαkinaseinhibitor1
Purity: 99.90%
Packaging: 25mg
Price: $990
Updated: 2021/12/16

ChemScene

Product number: CS-0042281
Product name: PDGFRαkinaseinhibitor1
Purity: 99.90%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0042281
Product name: PDGFRαkinaseinhibitor1
Purity: 99.90%
Packaging: 100mg
Price: $2500
Updated: 2021/12/16

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PDGFRα kinase inhibitor 1 Chemical Properties,Usage,Production

Biological Activity

PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1]. PDGFRα kinase inhibitor 1 (CHMFL-PDGFR-159, Compound 15i) exhibits weak inhibition to DDR1 kinase (IC50: 2462±126 nM)[1].

References

[1]. Wang Q, et al. Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia. Eur J Med Chem. 2018 Apr 25;150:366-384.

PDGFRα kinase inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PDGFRα kinase inhibitor 1 Suppliers

China 10 United States 2 Global 12

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2209053-93-8, PDGFRα kinase inhibitor 1Related Search:

PDGFRα kinase inhibitor 1

3-Pyridinecarboxamide, N-[2-(dimethylamino)ethyl]-N-[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]-

PDGFRα kinase inhibitor 1

2209053-93-8

C34H34N8O2