ChemicalBook > CAS DataBase List > PDGFRα kinase inhibitor 1
PDGFRα kinase inhibitor 1
- Product Name
- PDGFRα kinase inhibitor 1
- CAS No.
- 2209053-93-8
- Chemical Name
- PDGFRα kinase inhibitor 1
- Synonyms
- PDGFRα kinase inhibitor 1;3-Pyridinecarboxamide, N-[2-(dimethylamino)ethyl]-N-[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]-
- CBNumber
- CB54845039
- Molecular Formula
- C34H34N8O2
- Formula Weight
- 586.69
- MOL File
- 2209053-93-8.mol
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PDGFRα kinase inhibitor 1 Property
- Density
- 1.271±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 260 mg/mL (443.16 mM; Need ultrasonic)
- pka
- 13.06±0.70(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0042281
- Product name
- PDGFRαkinaseinhibitor1
- Purity
- 99.90%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0042281
- Product name
- PDGFRαkinaseinhibitor1
- Purity
- 99.90%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0042281
- Product name
- PDGFRαkinaseinhibitor1
- Purity
- 99.90%
- Packaging
- 25mg
- Price
- $990
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0042281
- Product name
- PDGFRαkinaseinhibitor1
- Purity
- 99.90%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0042281
- Product name
- PDGFRαkinaseinhibitor1
- Purity
- 99.90%
- Packaging
- 100mg
- Price
- $2500
- Updated
- 2021/12/16
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PDGFRα kinase inhibitor 1 Chemical Properties,Usage,Production
Biological Activity
PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1]. PDGFRα kinase inhibitor 1 (CHMFL-PDGFR-159, Compound 15i) exhibits weak inhibition to DDR1 kinase (IC50: 2462±126 nM)[1].
References
[1]. Wang Q, et al. Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia. Eur J Med Chem. 2018 Apr 25;150:366-384.
PDGFRα kinase inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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PDGFRα kinase inhibitor 1 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
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- Advantage
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- Tel
- support@targetmol.com
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- United States
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