TCO-PEG8-amine Property

Boiling point:

639.9±55.0 °C(Predicted)

Density 

1.11±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

11.95±0.46(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

TCO-PEG8-amine Chemical Properties,Usage,Production

Description

TCO-PEG8-amine is an aqueous soluble heterobifunctional crosslinker consisting of a TCO and an amine group (NH2). Amine is very reactive with active NHS ester or with carboxylic acid in the presence of of activators suh as EDC. TCO moiety enable click chemistry with tetrazine molecule. The inverse-electron demand Diels-Alder cycloaddition of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity.