ChemicalBook > CAS DataBase List > 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product Name: 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.: 1357349-91-7
Chemical Name: 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms: SPP 86;SPP86 >=98% (HPLC);SPP-86, 10 mM in DMSO;Inhibitor,inhibit,SPP-86,SPP 86,SPP86,RET;1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-
CBNumber: CB54902611
Molecular Formula: C16H15N5
Formula Weight: 277.32
MOL File: 1357349-91-7.mol

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1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Property

Boiling point:: 495.3±40.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 3.95±0.30(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5391
Product name: SPP86
Purity: ≥98%(HPLC)
Packaging: 10
Price: $219
Updated: 2021/12/16

Tocris

Product number: 5391
Product name: SPP86
Purity: ≥98%(HPLC)
Packaging: 50
Price: $918
Updated: 2021/12/16

TRC

Product number: S681745
Product name: SPP86
Packaging: 10mg
Price: $200
Updated: 2021/12/16

Usbiological

Product number: 256731
Product name: SPP 86
Packaging: 10mg
Price: $475
Updated: 2021/12/16

ChemScene

Product number: CS-0033057
Product name: SPP-86
Purity: >99.0%
Packaging: 1mg
Price: $150
Updated: 2021/12/16

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1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemical Properties,Usage,Production

Uses

SPP 86 is a potent RET Kinase inhibitor.

Biological Activity

SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC50 value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated activation of the PI3K/Akt and MAPK pathways at doses of 0.1- 1 μM in a cell line expressing oncogenic RET and inhibited RET-induced ERα phosphorylation and proliferation in MCF7 cells with an IC50 value of 1.0 μM, similar to tamoxifen.

storage

Store at +4°C

1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Suppliers

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1357349-91-7, 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineRelated Search:

1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

SPP 86

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-

SPP86 >=98% (HPLC)

Inhibitor,inhibit,SPP-86,SPP 86,SPP86,RET

1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

SPP-86, 10 mM in DMSO

1357349-91-7