5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
- Product Name
- 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
- CAS No.
- 1776116-74-5
- Chemical Name
- 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
- Synonyms
- MC 1742;MC1742,MC-1742;5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide;Pentanamide, 5-[(4-[1,1'-biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxy-
- CBNumber
- CB54902828
- Molecular Formula
- C21H21N3O3S
- Formula Weight
- 395.47
- MOL File
- 1776116-74-5.mol
5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Property
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mM
- form
- A solid
- pka
- 7.51±0.50(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 29171
- Product name
- MC1742
- Packaging
- 5mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 29171
- Product name
- MC1742
- Packaging
- 10mg
- Price
- $911
- Updated
- 2024/03/01
- Product number
- 29171
- Product name
- MC1742
- Packaging
- 1mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- M479003
- Product name
- MC1742
- Packaging
- 1mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 7289EM
- Product name
- N-Hydroxy-5-[[6-oxo-4-(4-phenylphenyl)-1H-pyrimidin-2-yl]sulfanyl]pentanamide
- Packaging
- 1mg
- Price
- $268
- Updated
- 2021/12/16
5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Chemical Properties,Usage,Production
Uses
MC 1742 is a novel histone deacetylase inhibitor, which has been shown to induce growth arrest, apoptosis and differentiation in sarcoma cancer stem cells.
Biological Activity
MC1742 is a uracil-based hydroxyamide (UBHA) th at acts as a subtype-selective histone deacetylases (HDACs) inhibitor (IC50: class I HDAC1/2/3/8 = 100/110/20/610 nM, class IIB HDAC6/10 = 7/40 nM, class IV HDAC11 = 100 nM, class IIA HDAC4/5/7/9 >50 μM). MC1742 exerts greater antiproliferation potency than SAHA in sarcoma cancer stem cell (CSC) cultures (MC1742/SAHA IC50 in μM = 0.25/1/RD, 1.12/1.13//MG-63, 1.4/3.92/SK-ES-1 post 72-hr treatment) and effectively reactivates HIV from latency (EC50 = 350 nM; JL at 10.6 cells) by upregulating histone acetylation at the HIV promoter without activating T cells.
storage
Store at -20°C