2-FLUORO-6-HYDROXYBENZONITRILE
- Product Name
- 2-FLUORO-6-HYDROXYBENZONITRILE
- CAS No.
- 140675-43-0
- Chemical Name
- 2-FLUORO-6-HYDROXYBENZONITRILE
- Synonyms
- 2-CYANO-3-FLUOROPHENOL;6-FLUOROSALICYLONITRILE;2-fuoro-6-hydroxybenzonitrle;2-fluoro-6-hydroxybenzonitrle;2-FLUORO-6-HYDROXYBENZONITRILE;Benzonitrile, 2-fluoro-6-hydroxy-;2-Fluoro-6-hydroxybenzonitrile >2-Fluoro-6-hydroxybenzonitrile 99%;2-FLUORO-6-HYDROXYBENZONITRILE,98+%;Benzonitrile, 2-fluoro-6-hydroxy- (9CI)
- CBNumber
- CB5494132
- Molecular Formula
- C7H4FNO
- Formula Weight
- 137.11
- MOL File
- 140675-43-0.mol
2-FLUORO-6-HYDROXYBENZONITRILE Property
- Melting point:
- 156-158°C
- Boiling point:
- 257.5±25.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 6.17±0.10(Predicted)
- color
- White to Light yellow
- BRN
- 8403914
- InChI
- InChI=1S/C7H4FNO/c8-6-2-1-3-7(10)5(6)4-9/h1-3,10H
- InChIKey
- YEBHNFDMNFHZFF-UHFFFAOYSA-N
- SMILES
- C(#N)C1=C(O)C=CC=C1F
- CAS DataBase Reference
- 140675-43-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/22-36/37/38
- Safety Statements
- 26-36/37/39
- RIDADR
- 3276
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0985
- Product name
- 2-Fluoro-6-hydroxybenzonitrile
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $21
- Updated
- 2025/07/31
- Product number
- F0985
- Product name
- 2-Fluoro-6-hydroxybenzonitrile
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- F596183
- Product name
- 2-Fluoro-6-hydroxybenzonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- F596183
- Product name
- 2-Fluoro-6-hydroxybenzonitrile
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 008753
- Product name
- 2-Fluoro-6-hydroxybenzonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $11
- Updated
- 2021/12/16
2-FLUORO-6-HYDROXYBENZONITRILE Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Synthesis
94088-46-7
140675-43-0
General procedure for the synthesis of 2-fluoro-6-hydroxybenzonitrile from 2-fluoro-6-methoxybenzonitrile: 1. 151 g (1 mol) of 2-fluoro-6-methoxybenzonitrile and 346.5 g (3 mol) of aqueous pyridinium solution were added to a 2 liter flask. Hydrogen chloride gas was slowly passed into the flask under a protective atmosphere. 2. The reaction mixture was slowly heated to 190 °C and stirred at this temperature for 5 hours. 3. Upon completion of the reaction, the mixture was cooled to room temperature overnight with slow stirring. 4. 1000 ml of water was added to the cooled mixture, and the mixture was heated to 80 °C. 5. 1000 ml of methyl tert-butyl ether was added and mixed thoroughly to separate the organic and aqueous phases. The aqueous phase was back-extracted twice with 500 ml of methyl tert-butyl ether. 6. Combine all the methyl tert-butyl ether phases and wash once with 800 ml of 10% aqueous sodium hydroxide and once with 400 ml of water. 7. Combine the two aqueous phases and adjust the pH to 2 with concentrated hydrochloric acid, then extract three times with 500 ml of dichloromethane. 8. The organic phases were combined and washed once with 10% hydrochloric acid. 9. The organic phases were dried with anhydrous sodium sulfate. 10. Finally, the solvent was removed by distillation under vacuum to give 120 g (87% yield) of 2-fluoro-6-hydroxybenzonitrile with >99% purity, and the product was confirmed by GC and 1H NMR (D6-dimethylsulfoxide, δ=6.85 ppm (m,2H,aryl H), 7.55 ppm (q,1H,aryl H), 11.7 ppm (s,1H,OH)) structure.
References
[1] Patent: WO2006/56433, 2006, A2. Location in patent: Page/Page column 30
[2] Patent: WO2007/93530, 2007, A1. Location in patent: Page/Page column 244-245
2-FLUORO-6-HYDROXYBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
2-FLUORO-6-HYDROXYBENZONITRILE Suppliers
- Tel
- 021-31038972,31038973 17321035817
- Fax
- +86-21-51385350
- sales@harvest-chem.com
- Country
- China
- ProdList
- 2816
- Advantage
- 64
- Tel
- 13013943931 15152133928
- xinyikangda@163.com
- Country
- China
- ProdList
- 610
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 847-367-3680
- Fax
- 847-367-3681
- sales@arkpharminc.com
- Country
- United States
- ProdList
- 1670
- Advantage
- 56
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2807
- Advantage
- 65
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
View Lastest Price from 2-FLUORO-6-HYDROXYBENZONITRILE manufacturers
- Product
- 2-FLUORO-6-HYDROXYBENZONITRILE 140675-43-0
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-18
- Product
- 2-FLUORO-6-HYDROXYBENZONITRILE 140675-43-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-FLUORO-6-HYDROXYBENZONITRILE 140675-43-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09