ChemicalBook > CAS DataBase List > JKC-363

JKC-363

Product Name: JKC-363
CAS No.: 436083-30-6
Chemical Name: JKC-363
Synonyms: JKC-363;JKC 363 TFA;(DeaMino-Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide;(Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide;(DEAMINO-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE;MPR-GLU-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2;(Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide, JKC-363;(DEAMINO-CYS11,D-ALA(2-NAPHTHYL)14,CYS18)-BETA-MSH (11-22) AMIDE;3-MERCAPTOPROPIONYL-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2;(Deamino-Cys11,D-2-Nal1?,Cys1?)-β-MSH (11-22) amide trifluoroacetate salt
CBNumber: CB5496444
Molecular Formula: C69H91N19O16S2
Formula Weight: 1506.71
MOL File: Mol file

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JKC-363 Property

Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: -15°C
form: Powder
pka: 4.07±0.10(Predicted)
color: White to off-white
Water Solubility: Soluble to 1 mg/ml in water
Sequence: {Mpa}-Glu-His-{D-2-Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Mpa1-Cys8)

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Safety

Safety Statements: 22-24/25

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 3426
Product name: JKC363
Packaging: 500U
Price: $137
Updated: 2021/12/16

Usbiological

Product number: 255555
Product name: JKC 363
Packaging: 500ug
Price: $395
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD109414
Product name: (Deamino-Cys11,D-2-Nal 14,Cys18)-b-MSH (11-22) amide trifluoroacetate salt
Packaging: 500ug
Price: $160
Updated: 2021/12/16

ApexBio Technology

Product number: B5428
Product name: JKC363
Packaging: 500ug
Price: $234
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD109414
Product name: (Deamino-Cys11,D-2-Nal 14,Cys18)-b-MSH (11-22) amide trifluoroacetate salt
Packaging: 1mg
Price: $275
Updated: 2021/12/16

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JKC-363 Chemical Properties,Usage,Production

Uses

JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2].

IC 50

MC4R

References

[1] Kim MS, et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. J Neuroendocrinol. 2002;14(4):276-282. DOI:10.1046/j.1365-2826.2002.00769.x
[2] Bellasio S, et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur J Pharmacol. 2003;482(1-3):127-132. DOI:10.1016/j.ejphar.2003.09.017

JKC-363 Preparation Products And Raw materials

Raw materials

Preparation Products

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436083-30-6, JKC-363Related Search:

(Deamino-Cys11,D-2-Nal 14,Cys18)-b-MSH (11-22) amide trifluoroacetate salt

3-MERCAPTOPROPIONYL-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2

JKC-363

[DEAMINO-CYS11, B-(2-NAPHTHYL)-D-ALA14, CYS18]-BETA-MELANOCYTE STIMULATING HORMONE AMIDE FRAGMENT 11-22

(DEAMINO-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE

(DEAMINO-CYS11,D-ALA(2-NAPHTHYL)14,CYS18)-BETA-MSH (11-22) AMIDE

MPR-GLU-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2

[Deamino-Cys11, β-(2-Naphthyl)-D-Ala14, Cys18]-β-Melanocyte Stimulating Hormone Amide Fragment 11-22

Mpr-Glu-His-D-Nal(2)-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge Mpr1-Cys8)

(DeaMino-Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide

L-α-Asparagine, N-(3-mercapto-1-oxopropyl)-L-α-glutamyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-, cyclic (1→7)-disulfide

(Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide, JKC-363

(Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide

(Deamino-Cys11,D-2-Nal1?,Cys1?)-β-MSH (11-22) amide trifluoroacetate salt

(Deamino-Cys??,D-2-Nal??,Cys??)-β-MSH (11-22) amide trifluoroacetate salt

Mpr-Glu-His-D-2-Nal-Arg-Trp- Gly-Cys-Pro-Pro-Lys-Asp-NH2(Disulfide bond Mpr1-Cys8)

JKC 363 TFA

{Mpa}-Glu-His-{D-2-Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Mpa1-Cys8)

436083-30-6

C69H91N19O16S2