GW8510
- Product Name
- GW8510
- CAS No.
- 222036-17-1
- Chemical Name
- GW8510
- Synonyms
- GW-8510 (GW8510;4-(((7-Oxo-6,7-dihydro-8H-thiazolo[5,4-e]indol-8-ylidene)methyl)amino)-N-(pyridin-2-yl)benzenesulfonamide;4-{[(7-oxo-6,7-dihydro-8h-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-n-(2-pyridyl)benzenesulfonamide;Benzenesulfonamide, 4-[[(6,7-dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinyl-
- CBNumber
- CB5498145
- Molecular Formula
- C21H15N5O3S2
- Formula Weight
- 449.51
- MOL File
- 222036-17-1.mol
GW8510 Property
- Density
- 1.635±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble
- form
- solid
- pka
- 8.39±0.10(Predicted)
- color
- Light yellow to yellow
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- KIN0000124
- Product name
- GW8510
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $651.13
- Updated
- 2021/12/16
- Product number
- KIN0000124
- Product name
- GW8510
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $967.48
- Updated
- 2021/12/16
GW8510 Chemical Properties,Usage,Production
Uses
GW8510 is a potent cyclin-dependent kinase-2 (CDK2) inhibitor. GW8510 is also a ribonucleotide reductase M2 (RRM2) inhibitor. GW8510 exhibits neuroprotective and anticancer activities[1][2][3].
Definition
ChEBI: 4-[(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methylamino]-N-(2-pyridinyl)benzenesulfonamide is a sulfonamide and a member of benzenes.
Biochem/physiol Actions
Initially characterized as an inhibitor of cyclin-dependent kinase 2 (CDK2), subsequent research has shown GW8510 to be non-selective.
in vivo
Combination with GW8510 and Tamoxifen enhances tumoricidal effect on Tamoxifen-resistant BBC xenograft through autophagy induction[3].
IC 50
CDK2; CDK5; RRM2
References
[1] ARCAMONE F, et, al. STRUCTURE AND SYNTHESIS OF DISTAMYCIN A. Nature. 1964 Sep 5;203:1064-5. DOI:10.1038/2031064a0
[2] Hiraku Y, et, al. Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis. Nucleic Acids Res Suppl. 2002;(2):95-6. DOI:10.1093/nass/2.1.95
[3] Majumder P, et, al. Effect of DNA groove binder distamycin A upon chromatin structure. PLoS One. 2011;6(10):e26486. DOI:10.1371/journal.pone.0026486
GW8510 Preparation Products And Raw materials
Raw materials
Preparation Products
GW8510 Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91