4,4'-Di-tert-butyl-2,2'-dipyridyl

Reaction

Product Name: 4,4'-Di-tert-butyl-2,2'-dipyridyl
CAS No.: 72914-19-3
Chemical Name: 4,4'-Di-tert-butyl-2,2'-dipyridyl
Synonyms: dbbpy;BBBPY;4,4'-Di-tert-butyl-2,2'-bipyridyl;4,4'-Di-tert-butyl-2,2'-dipyidyl;2,2'-Bipyridine,4,4'-bis(1,1-diMethylethyl)-;4-tert-butyl-2-(4-tert-butylpyridin-2-yl)pyridine;Dtbpy;dtbbpy;l-2,2'-bipyridine;4,4'-DI-TERT-BUTYL BIPYRIDINE
CBNumber: CB5499526
Molecular Formula: C18H24N2
Formula Weight: 268.4
MOL File: 72914-19-3.mol

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4,4'-Di-tert-butyl-2,2'-dipyridyl Property

Melting point:: 159-161 °C(lit.)
Boiling point:: 395.4±42.0 °C(Predicted)
Density: 0.977
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: 5.15±0.30(Predicted)
form: crystal
color: white
Stability:: hygroscopic
InChI: InChI=1S/C18H24N2/c1-17(2,3)13-7-9-19-15(11-13)16-12-14(8-10-20-16)18(4,5)6/h7-12H,1-6H3
InChIKey: TXNLQUKVUJITMX-UHFFFAOYSA-N
SMILES: C1(C2=NC=CC(C(C)(C)C)=C2)=NC=CC(C(C)(C)C)=C1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
TSCA: No
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 515477
Product name: 4,4′-Di-tert-butyl-2,2′-dipyridyl
Purity: 98%
Packaging: 5g
Price: $134
Updated: 2025/07/31

Sigma-Aldrich

Product number: 515477
Product name: 4,4′-Di-tert-butyl-2,2′-dipyridyl
Purity: 98%
Packaging: 25g
Price: $389
Updated: 2025/07/31

TCI Chemical

Product number: D3134
Product name: 4,4'-Di-tert-butyl-2,2'-bipyridyl
Purity: >98.0%(GC)
Packaging: 1g
Price: $55
Updated: 2025/07/31

TCI Chemical

Product number: R0320
Product name: 4,4'-Di-tert-butyl-2,2'-bipyridyl (HPMC encapsulated)
Packaging: 10EACH
Price: $60
Updated: 2025/07/31

TCI Chemical

Product number: D3134
Product name: 4,4'-Di-tert-butyl-2,2'-bipyridyl
Purity: >98.0%(GC)
Packaging: 5g
Price: $194
Updated: 2025/07/31

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4,4'-Di-tert-butyl-2,2'-dipyridyl Chemical Properties,Usage,Production

Reaction

Ligand for the iridium-catalyzed borylation of arenes
Ligand for the iridium-catalyzed synthesis of arylboronic acids and aryl trifluoroborates
Ligand for the nickel-catalyzed hydroxycarboxylation of 1,2-dienes by reaction carbon dioxide and oxygen
Ligand for the iridium-catalyzed meta borylation followed by halogenation of 1,3-disubstituted arenes
Ligand for the iridium-catalyzed silyl-directed ortho-borylation of arenes
Ligand for the iridium-catalyzed silane borylation followed by aryl borylation
Ligand for the iridium-catalyzed microwave-accelerated borylation of aromatic C-H bonds
Ligand for the iridium-catalyzed silyl-directed borylation of indoles
Ligand for the nickel-catalyzed synthesis of functionalized dialkyl ketones from carboxylic acids and alkyl halides
Ligand for the iron-catalyzed arylation of heterocycles

Chemical Properties

white cyrstalline powder

Uses

4,4'-Di-tert-butyl-2,2'-dipyridyl acts as a reagent in the preparation, antiproliferative and cytotoxic activity of apoptotic ruthenium nitrogen heterocyclic complexes via combinatorial library synthesis.

Synthesis

3978-81-2

72914-19-3

In this embodiment, the synthesis of 4,4'-di-tert-butyl-2,2'-bipyridine from 4-tert-butylpyridine was investigated. This was done as follows: 4-tert-butylpyridine (0.5 mmol) was reacted with SD (1 to 2 molar equivalents) in THF (2 to 4 mL) at a reaction temperature of 50°C for a reaction time of 1 to 24 hours. Upon completion of the reaction, the reaction products were isolated and purified according to the method of Example 1 to obtain 4,4'-di-tert-butyl-2,2'-bipyridine (target product), 4-tert-butyl-1,4-dihydropyridine (byproduct 1), and 4,4',4''-tri-tert-butyl-2,2':6',2''-tripyridine (byproduct 3), and the respective yields were calculated. Also, the recovery of unreacted 4-tert-butylpyridine was calculated. The experimental results showed that the highest yield of 4,4'-di-tert-butyl-2,2'-bipyridine was achieved under the optimal conditions (0.5 mmol of 4-tert-butylpyridine reacted with 1 molar equivalent of SD in 4 mL of THF at 50 °C for 6 h) and no by-products were generated. In addition, the use of 2 molar equivalents of SD resulted in a lower yield and material balance. Comparison with Example 1 shows that decreasing the concentration of 4-tert-butylpyridine and SD relative to THF contributes to higher yields.

References

[1] Patent: US2018/282278, 2018, A1. Location in patent: Paragraph 0057; 0127-0130
[2] Helvetica Chimica Acta, 1980, vol. 63, # 6, p. 1675 - 1702
[3] Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 2000, # 1, p. 63 - 68
[4] Inorganica Chimica Acta, 2011, vol. 365, # 1, p. 127 - 132
[5] Synthesis (Germany), 2013, vol. 45, # 22, p. 3099 - 3102

4,4'-Di-tert-butyl-2,2'-dipyridyl Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-Di-tert-butyl-2,2'-dipyridyl Suppliers

Americas 1 Belgium 1 China 207 Europe 1 France 1 Germany 4 India 10 Japan 1 Switzerland 3 United Kingdom 8 United States 24 Global 261

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View Lastest Price from 4,4'-Di-tert-butyl-2,2'-dipyridyl manufacturers

Zhengzhou Alfa Chemical Co.,Ltd

Product: 4,4'-Di-tert-butyl-2,2'-bipyridine 72914-19-3
Price: US $10.00/g
Min. Order: 5g
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-06-28

Shanghai UCHEM Inc.

Product: 4,4'-Di-tert-butyl-2,2'-bipyridine 72914-19-3
Price: US $23.00-433.00/g
Min. Order: 1g
Purity: 0.98
Supply Ability: 10kg
Release date: 2024-04-12

Dideu Industries Group Limited

Product: 4,4'-Di-tert-butyl-2,2'-bipyridine 72914-19-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-28

72914-19-3, 4,4'-Di-tert-butyl-2,2'-dipyridylRelated Search:

4-tert-Butyltoluene Pyridine Cyclooctane 2,6-BIS(2-BENZIMIDAZOLYL)PYRIDINE 4-TERT-BUTYLPYRIDINE 4,4'-Dimethyl-2,2'-bipyridyl 4,4',4''-TRI-TERT-BUTYL-2,2':6',2''-TERPYRIDINE 4,4'-Di-tert-butyl-2,2'-dipyridyl

4,4'-Di-tert-butyl-2,2'-dipyidyl

l-2,2'-bipyridine

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4,4'-Di-O-tert-butyl-2,2'-bypyridine

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dbbpy

2,2'-Bipyridine,4,4'-bis(1,1-diMethylethyl)-

4,4'-Di-tert-butyl-2,2'-dipyridyl 98%

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4,4'-DI-TERT-BUTYL-2,2'-BYPYRIDINE

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4,4'-Bis(tert-butyl)-2,2'-bipyridine

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4,4'-Di-tert-butyl-2,2'-bipyridyl

BBBPY

4,4'-Bis(di-t-butyl)-2,2'-bipyridine, 97% DTBBPY

4,4'-di-tert-butyl bipyridine(dtbpy)

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4,4'-Di-tert-butyl-2,2'-bipyridyl&gt

4,4'-Di-tert-butyl-2,2'-bipyridine ISO 9001：2015 REACH

TIANFU-CHEM_4 4'-DI-TERT-BUTYL-2 2'-DIPYRIDYL 98

4′-Di-tert-butyl-2,2′-dipyridyl

4,4'-Di-tert-butyl-2,2'-dipyridyl

4,4′-Di-<i>tert</i>-butyl-2,2′-dipyridyl

dtbbpy

Dtbpy

72914-19-3

72941-19-3

Heterocycle-Pyridine series

Achiral Nitrogen

Py-N

C9 to C46

Heterocyclic Building Blocks

Pyridines