METHYL 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOATE
- Product Name
- METHYL 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOATE
- CAS No.
- 115933-50-1
- Chemical Name
- METHYL 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOATE
- Synonyms
- Methyl 4-hydroxy-3-(trifluoromethyl);Methyl 3-(trifluoroMethyl)-4-hydroxybenzoate;Benzoic acid, 4-hydroxy-3-(trifluoromethyl)-, methyl ester;4-hydroxy-3-(trifluoromethyl)-Benzoic acid methyl ester (9CI ACI);Benzoic acid, 4-hydroxy-3-(trifluoromethyl)-, methyl ester (9CI, ACI)
- CBNumber
- CB5501113
- Molecular Formula
- C9H7F3O3
- Formula Weight
- 220.15
- MOL File
- 115933-50-1.mol
METHYL 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOATE Property
- Melting point:
- 167-169 °C
- Boiling point:
- 266.1±40.0 °C(Predicted)
- Density
- 1.382±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 6.37±0.43(Predicted)
- Appearance
- White to light brown Solid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- M323388
- Product name
- Methyl4-hydroxy-3-(trifluoromethyl)benzoate
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 076535
- Product name
- Methyl 4-hydroxy-3-(trifluoromethyl)benzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- PC2901
- Product name
- Methyl4-hydroxy-3-(trifluoromethyl)benzoate
- Purity
- 98+%
- Packaging
- 5g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 076535
- Product name
- Methyl 4-hydroxy-3-(trifluoromethyl)benzoate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 2829-3-X4
- Product name
- Methyl 4-hydroxy-3-(trifluoromethyl)benzoate
- Purity
- 98.0%
- Packaging
- 5G
- Price
- $152
- Updated
- 2021/12/16
METHYL 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOATE Chemical Properties,Usage,Production
Synthesis
67-56-1
220239-68-9
115933-50-1
Step 1: Synthesis of methyl 4-hydroxy-3-(trifluoromethyl)benzoate 4-Hydroxy-3-(trifluoromethyl)benzoic acid (4.9 g, 23.7 mmol) was dissolved in a solvent mixture of methanol (15 mL) and DMF (18 μL, 0.24 mmol). Thionyl chloride (5.2 mL, 71.0 mmol) was slowly added dropwise under stirring, and the dropwise addition time was controlled within 10 min. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 18 hours. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (50 mL) and washed with saturated aqueous sodium bicarbonate (50 mL). The aqueous phase was then extracted with ethyl acetate (2 x 50 mL). All organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 4-hydroxy-3-(trifluoromethyl)benzoate (4.9 g, 93% yield) as an off-white solid. Product characterization data: 1H NMR (400 MHz, DMSO) δ 11.68 (s, 1H), 8.00-8.10 (m, 2H), 7.20-7.07 (m, 1H), 3.83 (s, 3H). ESI-MS m/z calculated: 220.0, measured: 221.0 (M + 1). Retention time: 1.41 min (3 min gradient).
References
[1] Organic Process Research and Development, 2015, vol. 19, # 6, p. 618 - 623
[2] Patent: WO2015/6280, 2015, A1. Location in patent: Paragraph 00344; 00345
[3] Patent: WO2011/93684, 2011, A2. Location in patent: Page/Page column 40
[4] Patent: WO2014/206344, 2014, A1. Location in patent: Page/Page column 104; 131
[5] Patent: US2007/191603, 2007, A1. Location in patent: Page/Page column 34
METHYL 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOATE Suppliers
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 18986259541
- Fax
- 027-87840182
- sales@3stc.com
- Country
- China
- ProdList
- 3763
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
View Lastest Price from METHYL 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOATE manufacturers
- Product
- METHYL 4-HYDROXY-3-(TRIFLUOROMETHYL)BENZOATE 115933-50-1
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02