ChemicalBook > CAS DataBase List > Anecortave Acetate

Anecortave Acetate

Product Name: Anecortave Acetate
CAS No.: 7753-60-8
Chemical Name: Anecortave Acetate
Synonyms: H6;Anecortave;Pregna-4,9(11)-diene-17-ol-3,20-dione-21-acetate;Al 3789;Retaane;NSC 15475;NSC 24345;Anacorta acetate;Anechota acetate;anecortave acetate
CBNumber: CB5501441
Molecular Formula: C23H30O5
Formula Weight: 386.48
MOL File: 7753-60-8.mol

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Anecortave Acetate Property

Melting point:: 230-234°C
alpha: D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3).
Boiling point:: 551.8±50.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.47±0.60(Predicted)
form: Solid
color: Off-White to Beige
InChIKey: YUWPMEXLKGOSBF-GACAOOTBSA-N
SMILES: C1(=O)C=C2[C@](C)(CC1)C1[C@]([H])([C@@]3([H])[C@@](CC=1)(C)[C@@](O)(C(=O)COC(C)=O)CC3)CC2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3649
Product name: Anecortave Acetate
Packaging: 5G
Price: $87
Updated: 2025/07/31

TRC

Product number: A637640
Product name: Anecortave
Packaging: 1g
Price: $900
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0000670
Product name: 17-HYDROXY-3,20-DIOXOPREGNA-4,9(11)-DIEN-21-YL ACETATE
Purity: 95.00%
Packaging: 100MG
Price: $1871.1
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17919
Product name: Anecortave acetate
Packaging: 25g
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17919
Product name: Anecortave acetate
Packaging: 50g
Price: $107.5
Updated: 2021/12/16

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Anecortave Acetate Chemical Properties,Usage,Production

Description

Anecortave acetate, an angiogenesis inhibitor, was launched in Australia by Alcon for the treatment of age-related macular degeneration (AMD). AMD is the leading cause of untreatable blindness among people aged 65 to 74 years in the U.S. Worldwide, approximately 20 to 25 million people suffer from AMD, a disease that until recently was untreatable. Anecortave, an angiostatic steroid, down-regulates the expression MMP-2 and -9 to exert its antiangiogenic effects.

Chemical Properties

Off-White Solid

Uses

As an angiostatic steroid, Anecortave Acetate can be used in treatment of macular degeneration.

Definition

ChEBI: Anecortave acetate is an organic molecular entity.

Synthesis

Anecortave has been synthesized by several different routes, and Pharmacia process patents are cited here. The synthesis is depicted in the scheme. Compound 1 was condensed with 2-chlorovinyl ethyl ether with n-BuLi in THF at low temperature to give a mixture of two isomeric aldehydes 2 in 91% yield. The mixture 2 was treated with acetic anhydride and anhydrous potassium acetate in DMF at 106??C to give acetate 3 which was reacted with RhCl(PPh3)3 and triethylsilane in methylene chloride at 45??C for 4 hours to yield the corresponding triethylsilane ether 4 as a solid after crystallization in hexane. Finally, compound 4 was oxidized with 40% peracetic acid in toluene at low temperature, and the reaction was quenched with SO2 in methanol (2M), and treated with TEA to give anecortave acetate

Enzyme inhibitor

This novel angiogenesis pro-drug (FW = 386.48 g/mol; CAS 7753-60-8) is taken up and metabolically de-esterified to form the aqnecortave, a synthetic steroid that suppresses the development and elongation of neovascular sprouts and tip cell motility in a VEGF-treated retinal explant model in a dose-dependent manner. Whether used as monotherapy or in combination with sub-therapeutic doses of cisplatin, anecortave acetate significantly controlled tumor burden in a murine retinoblastoma model.

Anecortave Acetate Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid 11-ALPHA-HYDROCORTISONE Hydrocortisone

Preparation Products

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Anecortave Acetate Suppliers

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View Lastest Price from Anecortave Acetate manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Anecortave Acetate 7753-60-8
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-30

Hebei Yanxi Chemical Co., Ltd.

Product: Anecortave Acetate 7753-60-8
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-08

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Hydrocortisone Impurity 30 7753-60-8
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-25

7753-60-8, Anecortave AcetateRelated Search:

Rimonabant Octreotide acetate Leuprorelin acetate Anecortave Impurity 2 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 17-acetate Anecortave Impurity 1 Anecortave Impurity 5 9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate

[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate

17-Hydroxypregna-4,9(11)-diene-3,20-dione-21-acetate

anecortave acetate

Anacorta acetate

Pregna-4,9(11)-diene-17-ol-3,20-dione-21-acetate

17-ALPHA-HYDROXY-3,20-DIOXOPREGNA-4,9(11)-DIENE-21-YL ACETATE

21-Acetoxy-17-hydroxypregna-4,9(11)-diene-3,20-dione

21-Acetoxy-17α-hydroxypregna-4,9(11)-diene-3,20-dione

3,20-Dioxopregna-4,9(11)-diene-17,21-diol 21-acetate

3,20-Dioxopregna-4,9(11)-diene-17α,21-diol 21-acetate

Pregna-4,9(11)-diene-17α,21-diol-3,20-dione 21-acetate

17-α,21-dihydroxypregna-4,9(11)-diene-3,20-dione 21-acetate

21-(Acetyloxy)-17-hydroxypregna-4,9(11)-diene-3,20-dione

21-Acetoxypregna- 4,9(11)-dien-17α-ol-3,20-dione

Al 3789

Anecortave

NSC 15475

NSC 24345

Retaane

ANECORTAVE ACETATE (200 MG)F0E2980.997MG/MG(AI)

Anecortave Acetate[H6]

Hydrocortisone Acetate EP Impurity E

Pregna-4,9(11)-diene-3,20-dione, 21-(acetyloxy)-17-hydroxy-

delta-9(11)-Hydrocortisone Acetate (Anecortave Acetate)

17-α,21-dihydroxypregna-4,9(11)-diene-3,20-dione 21-acetate

Anechota acetate

2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

Anecortave Acetate (H5)

17-Hydroxypregna-4,9(11)-dione-3,20-dione-21-Acetate （H6)

Acetate Aneconazole

Hydrocortisone ester

Hydrocortisone Aceate EP Impurity E

17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione 21-acetate(H6)

Acetic Acid Anacardic

Hydrocortisone Acetate Impurity 5

Hydrocortisone Acetate Impurity 5 (Hydrocortisone Acetate EP Impurity E)

7753-60-8

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