ChemicalBook > CAS DataBase List > ETHYL 6-HYDROXY-2-NAPHTHOATE

ETHYL 6-HYDROXY-2-NAPHTHOATE

Product Name
ETHYL 6-HYDROXY-2-NAPHTHOATE
CAS No.
17295-12-4
Chemical Name
ETHYL 6-HYDROXY-2-NAPHTHOATE
Synonyms
Naproxen Impurity 51;Ethyl6-hydroxy-2-naphtoate;ETHYL 6-HYDROXY-2-NAPHTHOATE;ethyl 6-hydroxynaphthalene-2-carboxylate;2-Naphthalenecarboxylic acid, 6-hydroxy-, ethyl ester
CBNumber
CB5501764
Molecular Formula
C13H12O3
Formula Weight
216.23
MOL File
17295-12-4.mol
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ETHYL 6-HYDROXY-2-NAPHTHOATE Property

Melting point:
139-140.5 °C(Solv: ethanol (64-17-5))
Boiling point:
378.7±15.0 °C(Predicted)
Density 
1.225±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
8.83±0.40(Predicted)
Appearance
Light brown to brown Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
8922AA
Product name
Ethyl6-hydroxy-2-naphthoate
Packaging
1g
Price
$138
Updated
2021/12/16
Matrix Scientific
Product number
083671
Product name
Ethyl 6-hydroxy-2-naphthoate
Purity
97%
Packaging
1g
Price
$360
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0166310
Product name
ETHYL-6-HYDROXY-2-NAPHTHOATE
Purity
98.00%
Packaging
5MG
Price
$501.57
Updated
2021/12/16
Alichem
Product number
17295124
Product name
Ethyl6-naphthol-2-carboxylate
Packaging
500mg
Price
$1019.2
Updated
2021/12/16
Alichem
Product number
17295124
Product name
Ethyl6-naphthol-2-carboxylate
Packaging
1g
Price
$1685
Updated
2021/12/16
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ETHYL 6-HYDROXY-2-NAPHTHOATE Chemical Properties,Usage,Production

Synthesis

64-17-5

16712-64-4

17295-12-4

1. 6-Hydroxy-2-naphthalenecarboxylic acid (5.29 g, 28.0 mmol) was dissolved in ethanol (50 mL) at 0 °C, and thionyl chloride (6 mL) was added slowly. 2. The reaction mixture was stirred at room temperature for 72 h. 3. Upon completion of the reaction, the excess reagent was removed by rotary evaporation. 4. The residue was dissolved in ethyl acetate (100 mL), and washed with water (80 mL), cold 1M sodium bicarbonate solution (80 mL) and brine (80 mL). 5. （The residue was dissolved in ethyl acetate (100 mL) and washed sequentially with water (80 mL), cold 1 M sodium bicarbonate solution (80 mL) and brine (80 mL). 5. The organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated to give ethyl 6-hydroxy-2-naphthoate in 99% yield. 6. The product was characterized by 1H NMR (CDCl3) and LCMS (APCl): 1H NMR (CDCl3): δ 8.53 (1H, br s), 8.5 (1H, br s), 8.3 (1H, br s), 8.4 (1H, br s). , br s), 8.01 (1H, dd, J = 8.5,1.7 Hz), 7.86 (1H, d, J = 8.5 Hz), 7.20-7.13 (2H, m), 4.43 (2H, q, J = 7.3 Hz), 1.43 (3H, t, J = 7.1 Hz). lcmS (apcl): 217.1 (m + h + ).

References

[1] Patent: WO2006/40646, 2006, A1. Location in patent: Page/Page column 97
[2] Journal of Physical Chemistry A, 2016, vol. 120, # 33, p. 6563 - 6574
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 14, p. 3518 - 3536
[4] Molecular Crystals and Liquid Crystals, 2008, vol. 494, p. 282 - 292
[5] Tetrahedron, 2013, vol. 69, # 43, p. 9045 - 9055

ETHYL 6-HYDROXY-2-NAPHTHOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 6-HYDROXY-2-NAPHTHOATE Suppliers

China 29 Germany 1 India 1 United Kingdom 2 United States 3 Global 36
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
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21-57721279
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China
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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chenyj@titansci.com
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Shanghai yirong biology science and technology co., ltd
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18049974220
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+86 (21) 51062076
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3060526242@qq.com
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China
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SynAsst Chemical.
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Chengdu Research Accelerators Technology Co., Ltd.
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028-64353063 QQ:784253935
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reacchemical@163.com
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Dalian lichuang Chemical Co., Ltd
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0411-0411-00000000 13644282108
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Aikon International Limited
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025-58859352 18068836627
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Zhengzhou Ruke Biological Co., Ltd.
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15981811963
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China
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Tianjin heowns Biochemical Technology Co., Ltd.
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400-6387771-6039 18920764717
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China
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Shanghai Han-Xiang Chemical Co., Ltd.
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15971444841
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18327183813
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amber@biochempartner.com
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17295-12-4, ETHYL 6-HYDROXY-2-NAPHTHOATERelated Search:

ethyl 5-ethoxy-2-nitrobenzoate Ethyl 5-iodo-2-methylbenzoate VIOMELLEIN Viriditoxin ETHYL 6-HYDROXY-2-NAPHTHOATE METHYL 6-HYDROXY-2-NAPHTHOATE RARECHEM AL BI 0342 6-Hydroxy-2-naphthoic acid

  • Ethyl6-hydroxy-2-naphtoate
  • 2-Naphthalenecarboxylic acid, 6-hydroxy-, ethyl ester
  • ETHYL 6-HYDROXY-2-NAPHTHOATE
  • ethyl 6-hydroxynaphthalene-2-carboxylate
  • Naproxen Impurity 51
  • 17295-12-4