1-METHYLPYRROLIDINE-2-THIONE
- Product Name
- 1-METHYLPYRROLIDINE-2-THIONE
- CAS No.
- 10441-57-3
- Chemical Name
- 1-METHYLPYRROLIDINE-2-THIONE
- Synonyms
- 1-METHYLPYRROLIDINE-2-THIONE;1-methyl-2-pyrrolidinethione;2-Pyrrolidinethione, 1-Methyl-;1-Methylpyrrolidine-2-thione>1-METHYLPYRROLIDINE-2-THIONE 97.0%+(GC)
- CBNumber
- CB5505838
- Molecular Formula
- C5H9NS
- Formula Weight
- 115.2
- MOL File
- 10441-57-3.mol
1-METHYLPYRROLIDINE-2-THIONE Property
- Melting point:
- 16 °C
- Boiling point:
- 145 °C / 15mmHg
- Density
- 1.09
- refractive index
- 1.5830 to 1.5870
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 1.74±0.20(Predicted)
- color
- Light yellow to Brown
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M1748
- Product name
- 1-Methylpyrrolidine-2-thione
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- M339563
- Product name
- 1-Methylpyrrolidine-2-thione
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR923785
- Product name
- 1-Methylpyrrolidine-2-thione
- Purity
- 96%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 7H67-1-0J
- Product name
- 1-Methylpyrrolidine-2-thione
- Purity
- 96%
- Packaging
- 1g
- Price
- $128
- Updated
- 2021/12/16
- Product number
- OR923785
- Product name
- 1-Methylpyrrolidine-2-thione
- Purity
- 96%
- Packaging
- 5g
- Price
- $130
- Updated
- 2021/12/16
1-METHYLPYRROLIDINE-2-THIONE Chemical Properties,Usage,Production
Synthesis
872-50-4
10441-57-3
The general procedure for the synthesis of 1-methylpyrrolidin-2-thione from N-methylpyrrolidone was as follows: N-methylpyrrolidone (0.75 mmol) was dissolved in tetrahydrofuran (THF, 5 mL) in a microwave reaction flask, followed by the addition of phosphorus pentasulfide/aluminum oxide (P2S5/Al2O3, 0.53 g, equivalent to 0.90 mmol of P2S5). After sealing the reaction vial, the suspension was placed in a CEM Discover? microwave reactor and heated by microwave radiation at 60 °C and 60 W power with stirring and air cooling. After 5 min of reaction, the completion of the reaction was confirmed by thin layer chromatography (TLC) monitoring. The reaction solution was cooled and quickly filtered through a short silica gel column. The reaction was first eluted with hexane to remove non-polar impurities, followed by a solvent mixture of hexane/ethyl acetate (EtOAc) to recover the target product 1-methylpyrrolidine-2-thione. Finally, the solvent was removed by distillation under reduced pressure to afford pure 1-methylpyrrolidine-2-thione in 92% yield.
References
[1] Organic Letters, 2012, vol. 14, # 2, p. 440 - 443
[2] Organic Syntheses, 1984, vol. 62, p. 158 - 158
[3] European Journal of Medicinal Chemistry, 1991, vol. 26, # 7, p. 687 - 697
[4] Tetrahedron, 1984, vol. 40, # 11, p. 2047 - 2052
[5] Tetrahedron Letters, 2011, vol. 52, # 40, p. 5131 - 5132
1-METHYLPYRROLIDINE-2-THIONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-METHYLPYRROLIDINE-2-THIONE manufacturers
- Product
- 1-Methylpyrrolidine-2-thione 10441-57-3
- Price
- US $10.00-100.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-03-06