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MOXISYLYTE

Product Name
MOXISYLYTE
CAS No.
54-32-0
Chemical Name
MOXISYLYTE
Synonyms
sympal;opilon;Vasoklin;arlytene;moxilite;moxisylyt;moxisylyte;timoxamina;thymoxamine;THYMOXAMINE HCL
CBNumber
CB5506264
Molecular Formula
C16H25NO3
Formula Weight
279.37
MOL File
54-32-0.mol
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MOXISYLYTE Property

storage temp. 
2-8°C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0008715
Product name
MOXISYLYTE
Purity
95.00%
Packaging
5MG
Price
$501.04
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008715
Product name
MOXISYLYTE
Purity
95.00%
Packaging
1G
Price
$1124.55
Updated
2021/12/16
Crysdot
Product number
CD12062995
Product name
4-(2-(Dimethylamino)ethoxy)-5-isopropyl-2-methylphenylacetate
Purity
95+%
Packaging
1g
Price
$608
Updated
2021/12/16
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MOXISYLYTE Chemical Properties,Usage,Production

Originator

Carlytene,Dedieu,France,1962

Uses

alpha-adrenergic blocker

Definition

ChEBI: Acetic acid [4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenyl] ester is a monoterpenoid.

Manufacturing Process

A hydrochloric acid solution of 100 g of thymol in alcohol is reacted with 72 g of sodium nitrite, the nitrosothymol (Organic Syntheses 6, New York, 1926, p. 92) thus obtained is introduced into ammonia, and is reduced by the introduction of hydrogen sulfide to 4-aminothymol (Organic Syntheses Coll. Vol. 1, New York, 1932, p. 458). 133.3 g of this 4-aminothymol are mixed with 67 g of sodium acetate, 107 g of glacial acetic acid and 80 g of acetic acid anhydride to form 4-acetaminothymol (Plancher, Gazzetta Chimica Italiana 25, II, p. 388). 156 parts by weight of this last formed substance dissolved in 600 cc of alcohol are added to a solution of 17.6 parts by weight of sodium in 600cc of alcohol, the mixture being boiled under reflux for some time with 82 g of dimethylaminoethyl chloride. The reaction product is treated with water, and neutralized with hydrochloric acid using acid Congo reagent indicator, and the alcohol is distilled off in vacuo. The base liberated by alkali is dissolved in ether. By evaporating the ether solution the dimethylaminoethyl ether of the 4-acetaminothymol is obtained as a brownish-yellow oil. After some time this oil solidifies in a crystalline state.
100 g of this base are dissolved in a mixture of 300 cc of concentrated hydrochloric acid (density 1.19) and 400 cc of water, and the solution is boiled for one hour under a reflux condenser. Thereupon it is made alkaline, extracted with ether, and the ether is distilled off. 23.6 g of the 4- aminothymoxyethyldimethylamine thus obtained are diazotized in the presence of sulfuric acid at a temperature not exceeding 0°C using a solution of 7.2 g of sodium nitrite in 70 cc of water, and the diazo compound is heated to boiling point after the addition of 1 g of copper sulfate, until no further gas is evolved. It is then made alkaline, and carbon dioxide is introduced. The base is precipitated first in an oily state, and soon becomes crystalline. The 4- oxythymoxyethyldimethylamine forms a neutral hydrochloride which is readily soluble in water, and has a melting point of 174°C to 175.5°C.
36.8 g of 4-oxythymoxyethyldimethylamine are boiled for one hour on a water bath with 160 cc of acetic anhydride and 17.5 cc of pyridine. After this period, the solution is diluted with water, made alkaline, and the base is extracted with ether and the ether distilled off. With acids, the base obtained forms crystalline salts which are readily soluble in water. The hydrochloride melts between 208°C and 210°C.

Therapeutic Function

Vasodilator

World Health Organization (WHO)

Moxisylyte was introduced in the late 1980s. It belongs to the group of a-adrenergic blocking agents. In France it is indicated for the treatment of manifestations of benign prostatic hypertrophy. It is also marketed in the UK at lower dosages for the treatment of peripheral vascular disorders (Raynaud's disease).

MOXISYLYTE Preparation Products And Raw materials

Raw materials

Preparation Products

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MOXISYLYTE Suppliers

Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
Aikon International Limited
Tel
025-58851090 13611564524
Fax
(6)02557626880
Email
lwan@aikonchem.com
Country
China
ProdList
15951
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15354
Advantage
58
Wuhan Yanzhe Technology Co., Ltd
Tel
15527250409
Fax
QQ:2692360204
Email
wenhaotian12@163.com
Country
China
ProdList
4495
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
17691182729 18161915376
Email
1046@dideu.com
Country
China
ProdList
10007
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Shanghai Haohong Scientific Co., Ltd.
Tel
400-400-8210725
Email
malulu@leyan.com
Country
China
ProdList
39990
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TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
Country
China
ProdList
8670
Advantage
58

54-32-0, MOXISYLYTERelated Search:


  • moxisylyte
  • opilon
  • sympal
  • thymoxamine
  • timoxamina
  • 4-(2-dimethylaminoethoxy)-5-isopropyl-2-methylphenyl acetate
  • Moxisylyte (base and/or unspecified salts)
  • Vasoklin
  • [4-(2-dimethylaminoethyloxy)-2-methyl-5-propan-2-ylphenyl] acetate
  • [4-(2-dimethylaminoethyloxy)-2-methyl-5-propan-2-yl-phenyl] ethanoate
  • acetic acid [4-(2-dimethylaminoethyloxy)-5-isopropyl-2-methyl-phenyl] ester
  • 2-(4-(2-(diMethylaMino)ethoxy)-5-isopropyl-2-Methylphenyl)acetic acid
  • 4-(2-(dimethylamino)ethoxy)-2-methyl-5-(1-methylethyl)-phenoacetate(ester
  • 4-(2-(dimethylamino)ethoxy)-2-methyl-5-(1-methylethyl)phenolacetate(ester)
  • 5-(2-(dimethylamino)ethoxy)-carvacroacetate(ester)
  • arlytene
  • moxilite
  • moxisylyt
  • THYMOXAMINE HCL
  • Phenol, 4-[2-(dimethylamino)ethoxy]-2-methyl-5-(1-methylethyl)-, 1-acetate
  • MOXISYLYTE USP/EP/BP
  • 54-32-0
  • C16H25NO3