PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI)

Product Name: PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI)
CAS No.: 441785-25-7
Chemical Name: PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI)
Synonyms: LB80331;Besifovir;Besifovir(b);Besifovir (LB8033);Besifovir, 10 mM in DMSO;[1-[(2-aminopurin-9-yl)methyl]cyclopropyl]oxymethylphosphonic acid;[1-[(2-amino-9-purinyl)methyl]cyclopropyl]oxymethylphosphonic acid;(1-((2-Amino-9H-purin-9-yl)methyl)cyclopropoxy)methylphosphonic acid;[[[1-[(2-Amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]phosphonic acid;LB80331,LB 80331,Inhibitor,Besifovir,LB-80331,HBV,Hepatitis B virus,inhibit
CBNumber: CB5511303
Molecular Formula: C10H14N5O4P
Formula Weight: 299.22
MOL File: 441785-25-7.mol

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PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI) Property

Boiling point:: 668.4±65.0 °C(Predicted)
Density: 1.94±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (835.51 mM)
form: Solid
pka: 2.44±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB168200
Product name: Besifovir
Packaging: 10mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB168200
Product name: Besifovir
Packaging: 25mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB168200
Product name: Besifovir
Packaging: 50mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0015550
Product name: Besifovir
Purity: 98.00%
Packaging: 5mg
Price: $170
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB168200
Product name: Besifovir
Packaging: 100mg
Price: $250
Updated: 2021/12/16

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PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI) Chemical Properties,Usage,Production

Uses

Besifovir (LB80331), a parent agent converted by LB80380 (HY-19447A), further metabolizes to its active form, LB80317.html" class="link-product" target="_blank"> LB80317 (HY-106235). Besifovir is an orally active, novel antiviral agent against hepatitis B virus (HBV)[1][2].

in vivo

The prodrug, LB80380, is rapidly absorbed after oral administration (30, 60, 120, 240 mg) and is converted to its parent drug, Besifovir (LB80331) (LB80380 was not detected in plasma). The median T_maxs of LB80331 ranged from 1.0 to 2.0 h postdosing. Thereafter, the plasma LB80331 concentration declined in a monoexponential manner, and the mean values of t_1/2 ranged from 2.5 to 3.3 h^[2].

References

[1] Jung JA, et al. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64. DOI:10.5414/cp201716
[2] Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83. PMID:17302367
[3] Lung-Yi Mak, et al. Pharmacokinetic evaluation of besifovir for the treatment of HBV infection. Expert Opin Drug Metab Toxicol. 2018 Jan;14(1):101-106. DOI:10.1080/17425255.2018.1417983

PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI) Suppliers

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441785-25-7, PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI)Related Search:

PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI) 1-(AMINOMETHYL)-CYCLOPROPANOL

[1-[(2-amino-9-purinyl)methyl]cyclopropyl]oxymethylphosphonic acid

PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI)

PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]-

(1-((2-Amino-9H-purin-9-yl)methyl)cyclopropoxy)methylphosphonic acid

P-[[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]-Phosphonic acid

[[[1-[(2-Amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]phosphonic acid

Besifovir

[1-[(2-aminopurin-9-yl)methyl]cyclopropyl]oxymethylphosphonic acid

Besifovir (LB8033)

Besifovir(b)

Phosphonic acid, P-[[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]-

LB80331,LB 80331,Inhibitor,Besifovir,LB-80331,HBV,Hepatitis B virus,inhibit

LB80331

Besifovir, 10 mM in DMSO

441785-25-7

C10H14N5O4P