Endovion

Product Name: Endovion
CAS No.: 265646-85-3
Chemical Name: Endovion
Synonyms: NS3728;Endovion;NS3728 >=98% (HPLC);Cl? Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728;1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea;Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
CBNumber: CB55419734
Molecular Formula: C16H9BrF6N6O
Formula Weight: 495.18
MOL File: 265646-85-3.mol

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Endovion Property

Density: 1.791±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol
pka: 3.95±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Water : < 0.1 mg/mL (insoluble)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Tocris

Product number: 6973
Product name: NS3728
Purity: ≥98%(HPLC)
Packaging: 50
Price: $669
Updated: 2021/12/16

TRC

Product number: N926063
Product name: NS3728
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0026942
Product name: Endovion
Purity: 99.27%
Packaging: 25mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-0026942
Product name: Endovion
Purity: 99.27%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0026942
Product name: Endovion
Purity: 99.27%
Packaging: 50mg
Price: $580
Updated: 2021/12/16

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Endovion Chemical Properties,Usage,Production

Biological Activity

Endovion (NS3728) is an anion channel inhibitor (eg chloride channel) and a specific VRAC/VSOAC blocker.

in vitro

Endovion (NS3728, 10-100 μM) reduces TNFα-induced apoptosis and increases p53-protein level as well as downstream signaling, eg, expression of p21 ^Waf1/Cip1 , Bax, Noxa, MDM2, and activation of Caspase-9/-3 in Cisplatin-sensitive cells.
Endovion (NS3728, 10 μM) inhibits cell proliferation in Capan-1, AsPC-1 and BxPC-3 cell lines.

Western Blot Analysis

< td class="col1"> Result:

Cell Line:	Wild -type, resistant, and transiently transfected A2780 cells.
Concentration:	10-100 μM. < /td>
Incubation Time:	18 or 4.5 h.
Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells. Resulted i n an increased LRRC8A protein expression. Significantly reduced p53 and ^p21Waf1/Cip1 protein level in A2780WT cells.

Cell Proliferation Assay

Cell Line:	Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines.
Concentration:	10 μM.
Incubation Time:	24 h.
Result:	Resulted in the most pronounced inhibition in all cell lines with 77 ± 26 % in Capan-1, 67 ± 9 % in AsPC-1, and 54 ± 8 % in BxPC-3 cells at +67 mV.

target

Chloride channel, VRAC/VSOAC.
ANO1.

storage

Store at -20°C

Endovion Preparation Products And Raw materials

Raw materials

Preparation Products

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Endovion Suppliers

China 30 United States 3 Global 33

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265646-85-3, EndovionRelated Search:

Endovion

NS3728

Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-

NS3728 >=98% (HPLC)

1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea

Cl? Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728

265646-85-3

CHBrFNO

C16H9BrF6N6O