ChemicalBook > CAS DataBase List > LHF-535
LHF-535
- Product Name
- LHF-535
- CAS No.
- 1450929-77-7
- Chemical Name
- LHF-535
- Synonyms
- LHF-535;LHF-535, 10 mM in DMSO;inhibit,LHF-535,Arenavirus,LHF 535,Inhibitor,LHF535;(Z)-2-(4-(2-(1-(4-Isopropoxyphenyl)-1H-benzo[d]imidazol-5-yl)vinyl)phenyl)propan-2-ol;Benzenemethanol, α,α-dimethyl-4-[(1Z)-2-[1-[4-(1-methylethoxy)phenyl]-1H-benzimidazol-5-yl]ethenyl]-;Benzenemethanol, a,a-dimethyl-4-[(1Z)-2-[1-[4-(1-methylethoxy)phenyl]-1H-benzimidazol-5-yl]ethenyl]-
- CBNumber
- CB55419769
- Molecular Formula
- C27H28N2O2
- Formula Weight
- 412.53
- MOL File
- 1450929-77-7.mol
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LHF-535 Property
- Boiling point:
- 597.9±52.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 96.67 mg/mL (234.34 mM; Need ultrasonic)
- form
- Solid
- pka
- 14.46±0.29(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
ApexBio Technology
- Product number
- BA1213
- Product name
- LHF-535
- Packaging
- 5mg
- Price
- $72
- Updated
- 2026/05/06
ApexBio Technology
- Product number
- BA1213
- Product name
- LHF-535
- Packaging
- 1mL(10mMinDMSO)
- Price
- $79
- Updated
- 2026/05/06
ApexBio Technology
- Product number
- BA1213
- Product name
- LHF-535
- Packaging
- 10mg
- Price
- $108
- Updated
- 2026/05/06
ApexBio Technology
- Product number
- BA1213
- Product name
- LHF-535
- Packaging
- 50mg
- Price
- $315
- Updated
- 2026/05/06
ApexBio Technology
- Product number
- BA1213
- Product name
- LHF-535
- Packaging
- 100mg
- Price
- $495
- Updated
- 2026/05/06
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LHF-535 Chemical Properties,Usage,Production
Uses
LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively[1].
in vivo
LHF-535 (3, 10 or 30 mg/kg; orally; daily; 14 days) protectes mice from a lethal challenge with Tacaribe virus and dramatically reduces viral titers in plasma, spleen, and liver[2].
An increase in survival is also observed when the first dose of LHF-535 (10 mg/kg) is delayed by 1, 2, or 3 days after infection in mice[2].
| Animal Model: | IFN-α/β and-γ receptor-deficient AG129 mice[2] |
| Dosage: | 3, 10, or 30 mg/kg/day |
| Administration: | Orally; daily; 14 days |
| Result: | Effective as a post-exposure therapeutic. |
References
[1] Dongcheng Dai, et al. Antiviral drugs for treatment of arenavirus infection. WO2013123215A2.
[2] Madu IG, et al. A potent Lassa virus antiviral targets an arenavirus virulence determinant. PLoS Pathog. 2018 Dec 21;14(12):e1007439. DOI:10.1371/journal.ppat.1007439
LHF-535 Preparation Products And Raw materials
Raw materials
Preparation Products
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