ChemicalBook > CAS DataBase List > N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
- Product Name
- N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
- CAS No.
- 143655-58-7
- Chemical Name
- N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
- Synonyms
- Exatecan Intermediate 6;N-(7-fluoro-8-methyl-4-oxo-tetralin-5-yl)acetamide;N-(7-fluoro-8-methyl-4-oxo-tetralin-5-yl)acetamide - [F82918];N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide;N-(3-Fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1-naphthalenyl)acetamide;N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrah ydronaphthalen-1-yl)acetamide;Acetamide, N-(3-fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1-naphthalenyl)-
- CBNumber
- CB55431451
- Molecular Formula
- C13H14FNO2
- Formula Weight
- 235.25
- MOL File
- 143655-58-7.mol
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N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Property
- Boiling point:
- 443.9±45.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- pka
- 13.73±0.20(Predicted)
- form
- Solid
- color
- Off-white to light brown
- InChI
- InChI=1S/C13H14FNO2/c1-7-9-4-3-5-12(17)13(9)11(6-10(7)14)15-8(2)16/h6H,3-5H2,1-2H3,(H,15,16)
- InChIKey
- PSNRFAKPOCIEDV-UHFFFAOYSA-N
- SMILES
- C(NC1=C2C(CCCC2=O)=C(C)C(F)=C1)(=O)C
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 3141DA
- Product name
- N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide
- Packaging
- 250mg
- Price
- $2085
- Updated
- 2021/12/16
A2B
- Product number
- AY07154
- Product name
- N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
- Purity
- 98%
- Packaging
- 5g
- Price
- $2348
- Updated
- 2021/12/16
A2B
- Product number
- AY07154
- Product name
- N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
- Purity
- 98%
- Packaging
- 100mg
- Price
- $271
- Updated
- 2021/12/16
A2B
- Product number
- AY07154
- Product name
- N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
- Purity
- 98%
- Packaging
- 250mg
- Price
- $425
- Updated
- 2021/12/16
A2B
- Product number
- AY07154
- Product name
- N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
- Purity
- 98%
- Packaging
- 1g
- Price
- $810
- Updated
- 2021/12/16
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N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Chemical Properties,Usage,Production
Uses
Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).
IC 50
Camptothecins
References
[1] Zhang, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998 A. 2020-07-31.
[2] Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. DOI:10.1111/j.1349-7006.1995.tb02468.x
N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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