RTA dh404

Product Name: RTA dh404
CAS No.: 1191265-33-4
Chemical Name: RTA dh404
Synonyms: CPD3619;RTA dh404;CDDO-dhTFEA (RTA dh404);CDDO-dhTFEA, 10 mM in DMSO;Olean-1-en-28-amide, 2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-;RTA dh 404,Nuclear factor-κB,Inhibitor,RTA dh-404,CDDOdhTFEA,Keap1-Nrf2,RTA dh404,Nuclear factor-kappaB,CDDO dhTFEA,CDDO-dhTFEA,inhibit,NF-κB;(4aS,6aR,6bR,8aR,12aR,12bR,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-N-(2,2,2-trifluoroethyl)-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,12b,13,14,14a,14b-octadecahydropicene-4a(2H)-carboxamide
CBNumber: CB55493695
Molecular Formula: C33H45F3N2O3
Formula Weight: 574.72
MOL File: 1191265-33-4.mol

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RTA dh404 Property

Boiling point:: 645.6±55.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 260 mg/mL (452.39 mM)
form: Solid
pka: 13.76±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0059303
Product name: CDDO-dhTFEA
Purity: 99.71%
Packaging: 5mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0059303
Product name: CDDO-dhTFEA
Purity: 99.71%
Packaging: 10mg
Price: $325
Updated: 2021/12/16

ChemScene

Product number: CS-0059303
Product name: CDDO-dhTFEA
Purity: 99.71%
Packaging: 25mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0059303
Product name: CDDO-dhTFEA
Purity: 99.71%
Packaging: 50mg
Price: $970
Updated: 2021/12/16

ChemScene

Product number: CS-0059303
Product name: CDDO-dhTFEA
Purity: 99.71%
Packaging: 100mg
Price: $1650
Updated: 2021/12/16

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RTA dh404 Chemical Properties,Usage,Production

Description

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB[1]. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats[2]. NF-κB Nrf2

Uses

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB[1]. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats[2].

IC 50

Nrf2; NF-κB

References

[1]. Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31. [2]. Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. Xenobiotica. 2014 Jun;44(6):570-8.

RTA dh404 Preparation Products And Raw materials

Raw materials

Preparation Products

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RTA dh404 Suppliers

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1191265-33-4, RTA dh404Related Search:

CPD3619

CDDO-dhTFEA (RTA dh404)

(4aS,6aR,6bR,8aR,12aR,12bR,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-N-(2,2,2-trifluoroethyl)-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,12b,13,14,14a,14b-octadecahydropicene-4a(2H)-carboxamide

RTA dh404

Olean-1-en-28-amide, 2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-

RTA dh 404,Nuclear factor-κB,Inhibitor,RTA dh-404,CDDOdhTFEA,Keap1-Nrf2,RTA dh404,Nuclear factor-kappaB,CDDO dhTFEA,CDDO-dhTFEA,inhibit,NF-κB

CDDO-dhTFEA, 10 mM in DMSO

1191265-33-4

C33H45F3N2O3

APIs