GNF4877

Product Name: GNF4877
CAS No.: 2041073-22-5
Chemical Name: GNF4877
Synonyms: GNF4877;CID 139600315;GNF-4877 GNF4877;CID 139600315(GNF-4877);3-Piperidinecarboxylic acid, 1-[3-[[[3-amino-6-[2-fluoro-5-(1-methylethoxy)phenyl]-2-pyrazinyl]carbonyl]amino]-4-pyridinyl]-, (3R)-;GNF 4877,GSK-3,inhibit,Glycogen synthase kinase-3,Glycogen synthase kinase 3,GNF-4877,GNF4877,Inhibitor,Dual specificity tyrosine regulated kinase,Dual specificity tyrosine phosphorylation regulated kinase,DYRK
CBNumber: CB55540441
Molecular Formula: C25H27FN6O4
Formula Weight: 494.52
MOL File: 2041073-22-5.mol

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GNF4877 Property

Boiling point:: 669.7±55.0 °C(Predicted)
Density: 1.367±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 4.17 mg/mL (8.43 mM and warming)
pka: 2.82±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2664
Product name: GNF-4877
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2664
Product name: GNF-4877
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $396
Updated: 2024/03/01

ChemScene

Product number: CS-0105879
Product name: GNF4877
Purity: 98.85%
Packaging: 5mg
Price: $700
Updated: 2021/12/16

ChemScene

Product number: CS-0105879
Product name: GNF4877
Purity: 98.85%
Packaging: 10mg
Price: $1100
Updated: 2021/12/16

ChemScene

Product number: CS-0105879
Product name: GNF4877
Purity: 98.85%
Packaging: 25mg
Price: $2100
Updated: 2021/12/16

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GNF4877 Chemical Properties,Usage,Production

Biological Activity

GNF4877 is a potent inhibitor of DYRK1A and GSK3β with IC50 values of 6 nM and 16 nM, respectively, resulting in blocked NFATc nuclear export and increased β-cell proliferation (EC50 for mouse β (R7T1) cells 0.66 μM).

in vitro

High glucose concentrations and glucokinase activators (GKAs) increase Ca ²⁺ signalling in β-cells, and increase intracellular Ca ²⁺ leads to activation of calcineurin and nuclear translocation of NFATc proteins. Indeed, concentrations of GNF4877 ((0.1 μM, 0.3 μM) well below the EC ₅₀ for β-cell proliferation are able to induce proliferation in the presence of high glucose or pharmacological activators of glucokinase. Finally, increasing intracellular Ca ²⁺ with glibenclamide (a sulfonylurea receptor 1 inhibitor) or Bay K8644 (an L-type Ca ²⁺ sup> channel activator) show additive activity with GNF4877.

in vivo

GNF4877 (50 mg/kg; oral gavage; twice a day; for 15 days; double transgenic RIP-DTA male mice) treatment induces β-cell proliferation, increases β-cell mass and insulin content, and improves glycaemic control.

Animal Model:	Double transgenic RIP-DTA male mice (Tg (Ins 2-rtTA) 2 Efr Tg (teto -DTA) 1 Gfi/J) with Doxycycline (28.8±2.4 g; 82±2 days)
Dosage:	50 mg/kg
Administration:	Oral gavage; twice a day; for 15 days
Result:	Induced β-cell proliferation, increased β-cell mass and insulin content, and improved glycaemic control.

target

GSK3β

16 nM (IC ₅₀ )

DYRK1A

6 nM (IC ₅₀ )

GNF4877 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNF4877 Suppliers

China 21 United States 2 Global 23

DC Chemicals

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Shanghai Lollane Biological Technology Co.,Ltd.

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ShangHai Biochempartner Co.,Ltd

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Chuzhou KeMail Chemical Technology Co., Ltd

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Luan lingxi Chemical Products Co., Ltd

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Zhejiang J&C Biological Technology Co.,Limited

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Chunchuang (Wuhan) Technology Co., Ltd

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cjbscvictory

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2041073-22-5, GNF4877Related Search:

GNF4877

CID 139600315

3-Piperidinecarboxylic acid, 1-[3-[[[3-amino-6-[2-fluoro-5-(1-methylethoxy)phenyl]-2-pyrazinyl]carbonyl]amino]-4-pyridinyl]-, (3R)-

CID 139600315(GNF-4877)

GNF 4877,GSK-3,inhibit,Glycogen synthase kinase-3,Glycogen synthase kinase 3,GNF-4877,GNF4877,Inhibitor,Dual specificity tyrosine regulated kinase,Dual specificity tyrosine phosphorylation regulated kinase,DYRK

GNF-4877 GNF4877

2041073-22-5