Fluclotizolam

Fluclotizolam Property

Boiling point:

524.0±60.0 °C(Predicted)

Density 

1.57±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: 5 mg/ml DMSO: 5 mg/ml DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml

pka

2.01±0.40(Predicted)

form 

A crystalline solid

λmax

241 nm

InChI

InChI=1S/C15H10ClFN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3

InChIKey

ZDYRCUZZLRLMHG-UHFFFAOYSA-N

SMILES

N12C(C)=NN=C1CN=C(C1=CC=CC=C1F)C1C=C(Cl)SC=12

Safety

WGK Germany 

WGK 2

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Fluclotizolam Chemical Properties,Usage,Production

Description

Fluclotizolam (Item No. 23524) is an analytical reference standard categorized as a thienotriazolodiazepine. This product is intended for research and forensic applications.

Chemical Properties

Flualprazolam (8-chloro-6-(2-fluorophenyl)-1-methyl-4H- [1,2,4]triazolo[4,3-a][1,4]benzodiazepine) is a triazolobenzodiazepine and is structurally similar to alprazolam. Flualprazolam is composed of a benzene ring fused to a seven-membered 1,4- diazepine ring. Flualprazolam also contains a fused triazolo ring. A methyl (-CH3) group is attached at the 1-position, a 2- fluorophenyl ring is attached at the 6-position, and a chlorine is attached at the 8-position of the triazolobenzodiazepine structure. Flualprazolam has a molecular formula of C17H12ClFN4 and a molecular weight of 326.76 g/mol.

History

Fluclotizolam is a thienotriazolodiazepine derivative which was first synthesised in 1979, but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified in 2017.

Uses

Fluclotizolam is one of the New Psychoactive Substancces (NPS).

Side effects

Fluclotizolam produces a sedative-hypnotic effect, often causing drowsiness, muscle relaxation and slowed, sluggish reactions. 

Regulatory Status

Flualprazolam is not currently controlled under the Controlled Substances Act. At the 2020 Commission on Narcotic Drugs Sixty-third session, the Commission decided to include flualprazolam in Schedule IV of the 1971 Convention on Psychotropic Substance.
https://www.deadiversion.usdoj.gov
https://www.federalregister.gov

References

1. Moosmann, B., and Auwrter, V. New Psychoactive Substances. Handbook of Experimental Pharmacology. Designer benzodiazepines: Another class of new psychoactive substances 252, 383-410 (2018).