ChemicalBook > CAS DataBase List > 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
- Product Name
- 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
- CAS No.
- 1353224-53-9
- Chemical Name
- 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
- Synonyms
- CMS-121;CMS-121, 10 mM in DMSO;4-(4-(cyclopentyloxy)quinolin-2-yl)be;1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;4-(4-(cyclopentyloxy)quinolin-2-yl)be nzene-1,2-diol (CMS121);ACC, Acetyl Coenzyme A Carboxylase,disease,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoA Carboxylase,CMS 121,dementia,ACC1,CMS-121
- CBNumber
- CB55540825
- Molecular Formula
- C20H19NO3
- Formula Weight
- 321.37
- MOL File
- 1353224-53-9.mol
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4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Property
- Boiling point:
- 511.0±50.0 °C(Predicted)
- Density
- 1.297±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 20 mg/ml
- form
- A crystalline solid
- pka
- 8.53±0.20(Predicted)
- color
- Light yellow to yellow
- InChI
- InChI=1S/C20H19NO3/c22-18-10-9-13(11-19(18)23)17-12-20(24-14-5-1-2-6-14)15-7-3-4-8-16(15)21-17/h3-4,7-12,14,22-23H,1-2,5-6H2
- InChIKey
- OMHNVUCFPJJLKD-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(C2C=C(OC3CCCC3)C3C(N=2)=CC=CC=3)C=C1O
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 27085
- Product name
- CMS121
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27085
- Product name
- 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27085
- Product name
- CMS121
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27085
- Product name
- CMS121
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-0119097
- Product name
- CMS-121
- Purity
- ≥99.0%
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
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4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Chemical Properties,Usage,Production
Uses
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3].
in vivo
CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism[1].
| Animal Model: | Female SAMP8 mice (9 months old)[1] |
| Dosage: | ~20 mg/kg/day |
| Administration: | Oral administration; daily; for 4 months |
| Result: | Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. |
References
[1] Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866. DOI:10.7554/eLife.47866
[2] Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89. DOI:10.1021/jm2012563
[3] Prior M, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13. DOI:10.1021/cn500051h
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Preparation Products And Raw materials
Raw materials
Preparation Products
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4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Suppliers
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View Lastest Price from 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- CMS121 1353224-53-9
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-21
Shenzhen Nexcon Pharmatechs Ltd.
- Product
- 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol 1353224-53-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 2000
- Release date
- 2025-06-05
Shaanxi Xianhe Biotech Co., Ltd
- Product
- 4-(4-(cyclopentyloxy)quinolin-2- yl)benzene-1,2-diol (CMS121) 1353224-53-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 1000KG
- Release date
- 2025-04-29