4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol

Product Name: 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
CAS No.: 1353224-53-9
Chemical Name: 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
Synonyms: CMS-121;CMS-121, 10 mM in DMSO;4-(4-(cyclopentyloxy)quinolin-2-yl)be;1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;4-(4-(cyclopentyloxy)quinolin-2-yl)be nzene-1,2-diol (CMS121);ACC, Acetyl Coenzyme A Carboxylase,disease,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoA Carboxylase,CMS 121,dementia,ACC1,CMS-121
CBNumber: CB55540825
Molecular Formula: C20H19NO3
Formula Weight: 321.37
MOL File: 1353224-53-9.mol

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4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Property

Boiling point:: 511.0±50.0 °C(Predicted)
Density: 1.297±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 20 mg/ml
form: A crystalline solid
pka: 8.53±0.20(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C20H19NO3/c22-18-10-9-13(11-19(18)23)17-12-20(24-14-5-1-2-6-14)15-7-3-4-8-16(15)21-17/h3-4,7-12,14,22-23H,1-2,5-6H2
InChIKey: OMHNVUCFPJJLKD-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(C2C=C(OC3CCCC3)C3C(N=2)=CC=CC=3)C=C1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27085
Product name: CMS121
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 27085
Product name: 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
Packaging: 25mg
Price: $456
Updated: 2024/03/01

Cayman Chemical

Product number: 27085
Product name: CMS121
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27085
Product name: CMS121
Packaging: 10mg
Price: $214
Updated: 2024/03/01

ChemScene

Product number: CS-0119097
Product name: CMS-121
Purity: ≥99.0%
Packaging: 5mg
Price: $300
Updated: 2021/12/16

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4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Chemical Properties,Usage,Production

Uses

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3].

in vivo

CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism^[1].

Animal Model:	Female SAMP8 mice (9 months old)^[1]
Dosage:	~20 mg/kg/day
Administration:	Oral administration; daily; for 4 months
Result:	Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain.

References

[1] Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866. DOI:10.7554/eLife.47866
[2] Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89. DOI:10.1021/jm2012563
[3] Prior M, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13. DOI:10.1021/cn500051h

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Suppliers

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View Lastest Price from 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: CMS121 1353224-53-9
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-21

Shenzhen Nexcon Pharmatechs Ltd.

Product: 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol 1353224-53-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 2000
Release date: 2025-06-05

Shaanxi Xianhe Biotech Co., Ltd

Product: 4-(4-(cyclopentyloxy)quinolin-2- yl)benzene-1,2-diol (CMS121) 1353224-53-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 1000KG
Release date: 2025-04-29

1353224-53-9, 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diolRelated Search:

CMS-121

1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-

4-(4-(cyclopentyloxy)quinolin-2-yl)be nzene-1,2-diol (CMS121)

ACC, Acetyl Coenzyme A Carboxylase,disease,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoA Carboxylase,CMS 121,dementia,ACC1,CMS-121

CMS-121, 10 mM in DMSO

4-(4-(cyclopentyloxy)quinolin-2-yl)be

1353224-53-9

CMS121