ChemicalBook > CAS DataBase List > dTAG-13
dTAG-13
- Product Name
- dTAG-13
- CAS No.
- 2064175-41-1
- Chemical Name
- dTAG-13
- Synonyms
- dTAG-13;FKBP12 PROTAC DTAG-13;(2S)-(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)amino)-2-oxoethoxy)phenyl)propyl 1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate, d-TAG-13;(1R)-3-(3,4-dimethoxyphenyl)-1-(2-{[(6-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}hexyl)carbamoyl]methoxy}phenyl)propyl (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate;2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester, (2S)-
- CBNumber
- CB55582346
- Molecular Formula
- C57H68N4O15
- Formula Weight
- 1049.17
- MOL File
- 2064175-41-1.mol
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dTAG-13 Property
- Melting point:
- 106-111°C
- Boiling point:
- 1134.0±65.0 °C(Predicted)
- Density
- 1.260±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMF (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.70±0.40(Predicted)
- color
- White to Off-White
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N-Bromosuccinimide Price
TRC
- Product number
- D710020
- Product name
- dTAG-13
- Packaging
- 10mg
- Price
- $2575
- Updated
- 2021/12/16
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dTAG-13 Chemical Properties,Usage,Production
Uses
dTAG-13 is a degradation tag which was tested for its efficiency at depleting FKBP12F36V -MELK(sg3R) and was found to have significantly degraded FKBP12F36V -MELK(sg3R) within 4 hours.Used in the study of cancer research.
Biological Activity
dTAG-13 is a degradation tag (dTAG) system heterobifunctional degrader composed of an E3 ubiquitin ligase cereblon (CRBN)-binding thalidomide moiety and an FKBP12(F36V) mutant-specific ligand AP1867 void of affinity for endogenous (wild-type) FKBP12, allowing selective degradation of target proteins of interest when expressed as an FKBP12(F36V) in-frame fusion (by transgene expression or locus-specific knock-in) by bridging them with CRBN for ubiquitination. dTAG-13 is shown to potently degrade FKBP12F36V-MELK(sg3R) in MDA-MB-468 cells (100 nM for 4 hrs) as well as ENL-FKBP12F36V-HA, but not endogenous ENL, in MV4;1 cells (500 nM for 0.5-1 hrs).
storage
Store at -20°C
dTAG-13 Preparation Products And Raw materials
Raw materials
Preparation Products
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dTAG-13 Suppliers
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2064175-41-1, dTAG-13Related Search:
(1R)-3-(3,4-dimethoxyphenyl)-1-[2-({[3-(2-{2-[3-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamido)propoxy]ethoxy}ethoxy)propyl]carbamoyl}methoxy)phenyl]propyl (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
RC32