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NTP-42

Product Name
NTP-42
CAS No.
2055599-51-2
Chemical Name
NTP-42
Synonyms
NTP-42;NTP42, 10 mM in DMSO;N-(tert-Butylcarbamoyl)-5-cyano-2-((4'-(difluoromethoxy)-[1,1'-biphenyl]-3-yl)oxy)benzenesulfonamide;pulmonary,Inhibitor,inhibit,PAH,NTP 42,NTP-42,NTP42,hypertension,TXA2,thromboxane,arterial,Prostaglandin Receptor;Benzenesulfonamide, 5-cyano-2-[[4'-(difluoromethoxy)[1,1'-biphenyl]-3-yl]oxy]-N-[[(1,1-dimethylethyl)amino]carbonyl]-
CBNumber
CB55582386
Molecular Formula
C25H23F2N3O5S
Formula Weight
515.53
MOL File
2055599-51-2.mol
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NTP-42 Property

Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 31.25 mg/mL (60.62 mM)
form 
Solid
pka
4.56±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0108127
Product name
NTP42
Purity
98.43%
Packaging
5mg
Price
$175
Updated
2021/12/16
ChemScene
Product number
CS-0108127
Product name
NTP42
Purity
98.43%
Packaging
10mg
Price
$275
Updated
2021/12/16
ChemScene
Product number
CS-0108127
Product name
NTP42
Purity
98.43%
Packaging
100mg
Price
$1125
Updated
2021/12/16
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NTP-42 Chemical Properties,Usage,Production

Uses

NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46619[1]. NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH)[2].

in vivo

NTP42 (0.25 mg/kg BID) is potent in a monocrotaline (MCT)-induced PAH rat model (28-day drug treatment is initiated within 24 h post-MCT) in haemodynamic assessments. NTP42 reduces the MCT-induced PAH, including mean pulmonary arterial pressure (mPAP) and right systolic ventricular pressure (RSVP). Moreover, NTP42 is superior to Sildenafil (HY-15025) and Selexipag (HY-14870) in significantly reducing pulmonary vascular remodelling, inflammatory mast cell infiltration and fibrosis in MCT-treated animals[2].

Animal Model:Male Wistar-Kyoto rats[2]
Dosage:0.25 mg/kg BID
Administration:28-day drug treatment was initiated within 24 h post-MCT (60 mg/kg)
Result:Reduced the MCT-induced PAH, including mPAP and RSVP.

IC 50

TXA2

References

[1] B. Therese KINSELLA, et al. Thromboxane receptor antagonists. WO2016203314A1.
[2] Eamon Mulvaney, et al. NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.

NTP-42 Preparation Products And Raw materials

Raw materials

Preparation Products

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NTP-42 Suppliers

China 36 United States 3 Global 39
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghaizehan biopharma technology co., Ltd.
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021-61350663 13052117465
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021-61350662
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sales@zehanbiopharma.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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Fujian boshi pharmaceutical technology co. LTD
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0595-22008920; 18120708884
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393612455@qq.com
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China
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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9729
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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sales@chemegen.com
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2055599-51-2, NTP-42Related Search:


  • NTP-42
  • Benzenesulfonamide, 5-cyano-2-[[4'-(difluoromethoxy)[1,1'-biphenyl]-3-yl]oxy]-N-[[(1,1-dimethylethyl)amino]carbonyl]-
  • pulmonary,Inhibitor,inhibit,PAH,NTP 42,NTP-42,NTP42,hypertension,TXA2,thromboxane,arterial,Prostaglandin Receptor
  • N-(tert-Butylcarbamoyl)-5-cyano-2-((4'-(difluoromethoxy)-[1,1'-biphenyl]-3-yl)oxy)benzenesulfonamide
  • NTP42, 10 mM in DMSO
  • 2055599-51-2
  • C25H23F2N3O5S