4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol

Product Name: 4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol
CAS No.: 1202764-53-1
Chemical Name: 4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol
Synonyms: B022;B022,B-022;4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol;4-(1-(2-Amino-5-chloropyrimidin-4-yl)indolin-6-yl)-2-(thiazol-2-yl)but-3-yn-2-ol;2-Thiazolemethanol, α-[2-[1-(2-amino-5-chloro-4-pyrimidinyl)-2,3-dihydro-1H-indol-6-yl]ethynyl]-α-methyl-
CBNumber: CB55582861
Molecular Formula: C19H16ClN5OS
Formula Weight: 397.88
MOL File: 1202764-53-1.mol

More

Less

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Property

Boiling point:: 644.4±65.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (628.33 mM)
form: Solid
pka: 10.71±0.29(Predicted)
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0078192
Product name: B022
Purity: 98.10%
Packaging: 5mg
Price: $205
Updated: 2021/12/16

ChemScene

Product number: CS-0078192
Product name: B022
Purity: 98.10%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0078192
Product name: B022
Purity: 98.10%
Packaging: 50mg
Price: $1250
Updated: 2021/12/16

ChemScene

Product number: CS-0078192
Product name: B022
Purity: 98.10%
Packaging: 100mg
Price: $2200
Updated: 2021/12/16

More

Less

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Chemical Properties,Usage,Production

Biological Activity

B022 is a potent and selective NF-κB-inducible kinase (NIK) inhibitor with Ki of 4.2 nM. B022 protects the liver from inflammation, oxidative stress and damage caused by toxins.

in vitro

B022 (0-5 μM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner.
B022 (0-5 μM; 12 hours; Hepa1 cells) treatment for 8 h completely blocks NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.

Western Blot Analysis

Cell Line:	Hepa1 cells
Concentration:	0 μM, 0.5 μM, 5 μM
Incubation Time:	12 hours
Result:	Suppressed NIK-induced p52 formation in a dose-dependent manner.	td>

RT-PCR

Cell Line:	Hepa1 cells
Concentration:	0 μM, 0.5 μM, 5 μM
Incubation Time:	12 hours
Result:	Dose-dependently blocked NIK-induced expression of chemokines, cytokines, and iNOS in these cells. Completely blocked NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.

< /span>

in vivo

B022 (30 mg/kg; intravenous injection; twice a day; for 10 days; STOP-NIK male mice) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses. < /p>

< tr>

Animal Model:	STOP-NIK male mice (8 weeks) infected with Ad-cre
Dosage:	30 mg/kg
Administration:	Intravenous injection; twice a day; for 10 days
Result:	Completely prevents the lethal effect of abnormally high levels of hepatic NIK in mice. Inhibited the majority of the deteriorating effects of aberrant activation of hepatic NIK.

target

Ki: 4.2 nM (NF-κB-inducing kinase (NIK))

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Suppliers

China 25 United States 4 Global 29

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Heze Development Zone chuangli Chemical Co., Ltd.

Tel: +86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
ProdList: 896
Advantage: 55

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Wuhan Anruike Pharmaceutical Technology Co., Ltd.

Tel: 18572841024
Fax: QQ：28128719
Email: 28128719@qq.com
Country: China
ProdList: 1985
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Hangzhou Synmed Pharmatech Co., Ltd.

Tel: 0571-56361269 17721302038
Email: sales@synmed.cn
Country: China
ProdList: 116
Advantage: 58

1202764-53-1, 4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-olRelated Search:

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol

B022

2-Thiazolemethanol, α-[2-[1-(2-amino-5-chloro-4-pyrimidinyl)-2,3-dihydro-1H-indol-6-yl]ethynyl]-α-methyl-

B022,B-022

4-(1-(2-Amino-5-chloropyrimidin-4-yl)indolin-6-yl)-2-(thiazol-2-yl)but-3-yn-2-ol

1202764-53-1