IZCZ-3

Product Name: IZCZ-3
CAS No.: 2223019-53-0
Chemical Name: IZCZ-3
Synonyms: IZCZ-3;IZCZ 3,IZCZ3;9-Ethyl-3-(1-(4-methoxyphenyl)-4,5-bis(4-(4-methylpiperazin-1-yl)phenyl)-1H-imidazol-2-yl)-9H-carbazole;9H-Carbazole, 9-ethyl-3-[1-(4-methoxyphenyl)-4,5-bis[4-(4-methyl-1-piperazinyl)phenyl]-1H-imidazol-2-yl]-;9-Ethyl-3-(1-(4-methoxyphenyl)-4,5-bis(4-(4-methylpiperazin-1-yl)phenyl)-1H-imidazol-2-yl)-9H-carbazole , IZCZ-3
CBNumber: CB55821227
Molecular Formula: C46H49N7O
Formula Weight: 715.93
MOL File: 2223019-53-0.mol

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IZCZ-3 Property

storage temp.: Store at -20°C
solubility: DMSO : 5 mg/mL (6.98 mM; ultrasonic and warming and heat to 80°C)
form: Solid
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

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IZCZ-3 Chemical Properties,Usage,Production

Biological Activity

IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity[1]. IZCZ-3 (2.1 μM-15.9 μM; 24 hours) significantly inhibits SiHa, HeLa, Huh7, and A375 cancer cell proliferation (IC50s of 3.3, 2.1，4.1, and 4.2 μM, respectively). IZCZ-3 induces only weak growth inhibition in the BJ fibroblasts (IC50=15.9 μM) and mouse mesangial cells (IC50=15.6 μM), suggesting that IZCZ-3 is more effective against cancer cells than against c-MYC-independent normal cells[1]. IZCZ-3 (0-5 μM; 12 hours) induces an apparent accumulation of cells in the G0/G1 phase in SiHa cells in a dose-dependent manner[1]. IZCZ-3 (20, 10, and 5 mg/kg; intraperitoneally; every other day for 24 days) inhibits tumor growth in BALB/c nude mice with SiHa human cervical squamous cancer xenograft[1].

References

[1]. Hu MH, et al. Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex. J Med Chem. 2018 Mar 22;61(6):2447-2459.

IZCZ-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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IZCZ-3 Suppliers

China 10 United States 4 Global 14

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
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Email: sales@chemegen.com
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ShangHai ChuanQian Chemcial Technique Centre

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Zhengzhou convergence chemical co., LTD

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Bide Pharmatech Ltd.

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Beijing Biocreative Technology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Tachizaki Biomedical Research Center

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2223019-53-0, IZCZ-3Related Search:

IZCZ-3

9H-Carbazole, 9-ethyl-3-[1-(4-methoxyphenyl)-4,5-bis[4-(4-methyl-1-piperazinyl)phenyl]-1H-imidazol-2-yl]-

IZCZ 3,IZCZ3

9-Ethyl-3-(1-(4-methoxyphenyl)-4,5-bis(4-(4-methylpiperazin-1-yl)phenyl)-1H-imidazol-2-yl)-9H-carbazole

9-Ethyl-3-(1-(4-methoxyphenyl)-4,5-bis(4-(4-methylpiperazin-1-yl)phenyl)-1H-imidazol-2-yl)-9H-carbazole , IZCZ-3

2223019-53-0

C46H49N7O