J22352
- Product Name
- J22352
- CAS No.
- 2252395-44-9
- Chemical Name
- J22352
- Synonyms
- J22352;J-22352,J22352;Benzamide, 4-[[3,4-dihydro-2,4-dioxo-3-(2-phenylethyl)-1(2H)-quinazolinyl]methyl]-N-hydroxy-
- CBNumber
- CB55821267
- Molecular Formula
- C24H21N3O4
- Formula Weight
- 415.44
- MOL File
- 2252395-44-9.mol
J22352 Property
- Density
- 1.343±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:125.0(Max Conc. mg/mL);300.88(Max Conc. mM)
- pka
- 8.91±0.10(Predicted)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-0090795
- Product name
- J22352
- Purity
- 99.73%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0090795
- Product name
- J22352
- Purity
- 99.73%
- Packaging
- 10mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- CS-0090795
- Product name
- J22352
- Purity
- 99.73%
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0090795
- Product name
- J22352
- Purity
- 99.73%
- Packaging
- 100mg
- Price
- $940
- Updated
- 2021/12/16
J22352 Chemical Properties,Usage,Production
Description
J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1.
in vitro
The consequences of decreased HDAC6 expression in response to J22352 decreased cell migration, increased autophagic cancer cell death and significant tumor growth inhibition. Notably, J22352 reduced the immunosuppressive activity of PD-L1, leading to the restoration of host anti-tumor activity. These results demonstrate that J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma._x000D_ _x000D_ Reference: Biochem Pharmacol. 2019 May;163:458-471. https://pubmed.ncbi.nlm.nih.gov/30885763/
in vivo
The consequences of decreased HDAC6 expression in response to J22352 decreased cell migration, increased autophagic cancer cell death and significant tumor growth inhibition. Notably, J22352 reduced the immunosuppressive activity of PD-L1, leading to the restoration of host anti-tumor activity. These results demonstrate that J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma._x000D_ _x000D_ Reference: Biochem Pharmacol. 2019 May;163:458-471. https://pubmed.ncbi.nlm.nih.gov/30885763/
target
J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM.
J22352 Preparation Products And Raw materials
Raw materials
Preparation Products
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