T-448
- Product Name
- T-448
- CAS No.
- 1597426-53-3
- Chemical Name
- T-448
- Synonyms
- T-448;T 448,T448;T-448 fumarate salt
- CBNumber
- CB55821308
- Molecular Formula
- C21H24N4O5S
- Formula Weight
- 444.51
- MOL File
- 1597426-53-3.mol
T-448 Property
- storage temp.
- Store at -20°C, stored under nitrogen
- solubility
- DMSO : 16.67 mg/mL (43.13 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0087687
- Product name
- T-448
- Purity
- 98.86%
- Packaging
- 1mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0087687
- Product name
- T-448
- Purity
- 98.86%
- Packaging
- 5mg
- Price
- $980
- Updated
- 2021/12/16
- Product number
- CS-0087687
- Product name
- T-448
- Purity
- 98.86%
- Packaging
- 10mg
- Price
- $1500
- Updated
- 2021/12/16
T-448 Chemical Properties,Usage,Production
Biological Activity
T-448 is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons[1]. T-448 enhances the levels of H3K4 methylation, increased mRNA expression of neural plasticity-related genes including brain derived neurotrophic factor (Bdnf), and ameliorated learning dysfunction[1]. T-448 has minimal impact on the LSD1-GFI1B complex and a superior hematological safety profile in mice via the generation of a compact formyl-FAD adduct. T-448 increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction[1].T-448 increases H3K4 methylation in the brain without causing hematological side effects even at 100 mg/kg[1].
References
[1]. Matsuda S, et al. T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice. Neuropsychopharmacology. 2018 Dec 22.
T-448 Preparation Products And Raw materials
Raw materials
Preparation Products
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