NS-3-008（HCl）
- Product Name
- NS-3-008（HCl）
- CAS No.
- 1172854-54-4
- Chemical Name
- NS-3-008（HCl）
- Synonyms
- NS-3-008;NS-3-008（HCl）;NS-3-008 hydrochloride;NS-3-008 hydrochloride, 10 mM in DMSO;1-Benzyl-3-hexylguanidine hydrochloride;N-BENZYL-N'-HEXYLGUANIDINE HYDROCHLORIDE;N-BENZYL-N'-HEXYLGUANIDINE HYDROCHLORIDE;Guanidine,N-hexyl-N'-(phenylmethyl)-,hydrochloride(1:1);renal,inhibit,Ccl2,NS3008 hydrochloride,Hsd17b4,Stat5,transcriptional,Inhibitor,dysfunction,ameliorate,CKD,NS 3 008 hydrochloride,p65,G0s2
- CBNumber
- CB55851721
- Molecular Formula
- C14H24ClN3
- Formula Weight
- 269.82
- MOL File
- 1172854-54-4.mol
NS-3-008（HCl） Property
- form
- Solid
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L159182
- Product name
- N-BENZYL-N''-HEXYLGUANIDINE HYDROCHLORIDE
- Purity
- AldrichCPR
- Packaging
- 25MG
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- DC20478
- Product name
- NS-3-008HCl
- Purity
- >98%
- Packaging
- 100mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- DC20478
- Product name
- NS-3-008HCl
- Purity
- >98%
- Packaging
- 1g
- Price
- $1700
- Updated
- 2021/12/16
NS-3-008（HCl） Chemical Properties,Usage,Production
Uses
NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease[1].
in vivo
NS-3-008 (5 mg/kg; oral administration; daily; for 4 weeks; wild-type 5/6Nx mice) treatment results in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. The phosphorylation of Stat5 and p65 protein is decreased, and SUN concentrations and renal caspase 3/7 activity decreased in 5/6Nx mice treated with NS-03-08. The F4/80-positive area and F4/80 protein levels are decreased in 5/6Nx mice treated with NS-3-008[1].
References
[1] Matsunaga N, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov;13:262-273. DOI:10.1016/j.ebiom.2016.10.008
NS-3-008（HCl） Preparation Products And Raw materials
Raw materials
Preparation Products
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