ChemicalBook > CAS DataBase List > AZD8529 mesylate

AZD8529 mesylate

Product Name
AZD8529 mesylate
CAS No.
1314217-69-0
Chemical Name
AZD8529 mesylate
Synonyms
AZD-8529 Ms-OH;AZD8529 mesylate;AZD-8529 mesylate, 10 mM in DMSO;7-Methyl-5-(3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl)-2-(4-(trifluoromethoxy)benzyl)isoindolin-1-one methanesulfonate;Inhibitor,addiction,AZD-8529,AZD 8529,AZD8529,treatment,inhibit,receptor,mGluR,Metabotropic glutamate receptors,mGluR2,AZD8529 mesylate,nicotine,AZD 8529 mesylate
CBNumber
CB55867317
Molecular Formula
C25H28F3N5O6S
Formula Weight
583.58
MOL File
1314217-69-0.mol
More
Less

AZD8529 mesylate Property

storage temp. 
Store at -20°C
solubility 
DMSO: 41.67 mg/mL (71.40 mM)
form 
Solid
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0028526
Product name
AZD-8529mesylate
Purity
99.05%
Packaging
5mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0028526
Product name
AZD-8529mesylate
Purity
99.05%
Packaging
10mg
Price
$800
Updated
2021/12/16
ChemScene
Product number
CS-0028526
Product name
AZD-8529mesylate
Purity
99.05%
Packaging
25mg
Price
$1700
Updated
2021/12/16
ChemScene
Product number
CS-0028526
Product name
AZD-8529mesylate
Purity
99.05%
Packaging
50mg
Price
$2800
Updated
2021/12/16
ChemScene
Product number
CS-0028526
Product name
AZD-8529mesylate
Purity
99.05%
Packaging
100mg
Price
$4300
Updated
2021/12/16
More
Less

AZD8529 mesylate Chemical Properties,Usage,Production

Uses

AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes[1].

in vivo

AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys[1].
AZD-8529 mesylate (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats[1].

Animal Model:Sprague-Dawley rats[1]
Dosage:10 mg/kg, 30 mg/kg
Administration:Intraperitoneal injection; 2 hours before nicotine injections
Result:Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats.

IC 50

mGluR2: 285 nM (EC50)

References

[1] Justinova Z, et al. The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. Biol Psychiatry. 2015 Oct 1;78(7):452-62. DOI:10.1016/j.biopsych.2015.01.014

AZD8529 mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AZD8529 mesylate Suppliers

China 27 United States 6 Global 33
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Wuhan TCASChem Technology Co., Ltd.
Tel
027-86697669 13986148687
Fax
86-027-86697669
Email
sales@tcaschem.com
Country
China
ProdList
4001
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2988
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58

1314217-69-0, AZD8529 mesylateRelated Search:


  • AZD8529 mesylate
  • AZD-8529 Ms-OH
  • Inhibitor,addiction,AZD-8529,AZD 8529,AZD8529,treatment,inhibit,receptor,mGluR,Metabotropic glutamate receptors,mGluR2,AZD8529 mesylate,nicotine,AZD 8529 mesylate
  • 7-Methyl-5-(3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl)-2-(4-(trifluoromethoxy)benzyl)isoindolin-1-one methanesulfonate
  • AZD-8529 mesylate, 10 mM in DMSO
  • 1314217-69-0