ChemicalBook > CAS DataBase List > 1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-

1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-

Product Name
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
CAS No.
2253744-54-4
Chemical Name
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
Synonyms
Dooku1;Dooku1 (Yoda1 Analog);Dooku1, 10 mM in DMSO;Inhibitor,Dooku 1,Dooku-1,Dooku1,inhibit;1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
CBNumber
CB55872603
Molecular Formula
C13H9Cl2N3OS
Formula Weight
326.2
MOL File
2253744-54-4.mol
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1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Property

Boiling point:
526.5±60.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 125 mg/mL (383.20 mM)
pka
13.56±0.50(Predicted)
form 
Solid
color 
White to off-white
InChI
1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2
InChIKey
MNPOBXLPCWFONX-UHFFFAOYSA-N
SMILES
ClC(C=CC=C1Cl)=C1CSC2=NN=C(C3=CC=CN3)O2
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
6568
Product name
Dooku1
Purity
≥98%(HPLC)
Packaging
10
Price
$141
Updated
2021/12/16
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1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Chemical Properties,Usage,Production

Uses

Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1].

Biological Activity

Dooku1, an analog of Yoda1, is a potent and selective antagonist of the mechanosensitive Piezo1 channel th at inhibits endogenous Yoda1-activated channels. Dooku1 inhibits relaxation of relaxation of aorta caused by Yoda1.

in vivo

Dooku1 (10 μM incubate 20 min) selectively inhibits Yoda1-induced relaxation of aorta of wild-type male C57BL/6 mice[1].

Animal Model:wild-type male C57BL/6 mice’s aortic rings[1]
Dosage:10 μM
Administration:20 min
Result:Suppressed the Yoda1-induced relaxation.

storage

Store at +4°C

References

[1] Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. DOI:10.1111/bph.14188
[2] Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. DOI:10.1111/bph.14188

1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Suppliers

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2253744-54-4, 1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-Related Search:


  • 1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
  • Dooku1
  • Dooku1 (Yoda1 Analog)
  • Inhibitor,Dooku 1,Dooku-1,Dooku1,inhibit
  • Dooku1, 10 mM in DMSO
  • 2253744-54-4