ChemicalBook > CAS DataBase List > 1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-

1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-

Product Name
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
CAS No.
2253744-54-4
Chemical Name
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
Synonyms
Dooku1;Dooku1 (Yoda1 Analog);Dooku1, 10 mM in DMSO;Inhibitor,Dooku 1,Dooku-1,Dooku1,inhibit;1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
CBNumber
CB55872603
Molecular Formula
C13H9Cl2N3OS
Formula Weight
326.2
MOL File
2253744-54-4.mol
More
Less

1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Property

Boiling point:
526.5±60.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 125 mg/mL (383.20 mM)
pka
13.56±0.50(Predicted)
form 
Solid
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Tocris
Product number
6568
Product name
Dooku1
Purity
≥98%(HPLC)
Packaging
10
Price
$141
Updated
2021/12/16
More
Less

1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Chemical Properties,Usage,Production

Uses

Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1].

Biological Activity

Dooku1, an analog of Yoda1, is a potent and selective antagonist of the mechanosensitive Piezo1 channel th at inhibits endogenous Yoda1-activated channels. Dooku1 inhibits relaxation of relaxation of aorta caused by Yoda1.

in vivo

Dooku1 (10 μM incubate 20 min) selectively inhibits Yoda1-induced relaxation of aorta of wild-type male C57BL/6 mice[1].

Animal Model:wild-type male C57BL/6 mice’s aortic rings[1]
Dosage:10 μM
Administration:20 min
Result:Suppressed the Yoda1-induced relaxation.

storage

Store at +4°C

References

[1] Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. DOI:10.1111/bph.14188
[2] Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. DOI:10.1111/bph.14188

1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- Suppliers

China 54 United States 5 Global 59
Shanghai Raise Chemical Technology Co.,Ltd
Tel
15026594951
Fax
0556-5030632
Email
rs@raise-chem.com
Country
China
ProdList
4454
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2390
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58

2253744-54-4, 1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-Related Search:


  • 1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
  • Dooku1
  • Dooku1 (Yoda1 Analog)
  • Inhibitor,Dooku 1,Dooku-1,Dooku1,inhibit
  • Dooku1, 10 mM in DMSO
  • 2253744-54-4