Tauro-α-muricholic acid sodium salt Property

storage temp. 

Store at -20°C

solubility 

DMF: 10 mg/mL; DMSO: 10 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 1 mg/mL

form 

A crystalline solid

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Tauro-α-muricholic acid sodium salt Chemical Properties,Usage,Production

Description

Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC₅₀ = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid .¹ TαMCA is common in rodents but has also been found in small amounts in human serum.²

References

1. Sayin, S.I., Wahlstr?m, A., Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist Cell Metab. 17(2),225-235(2013).
2. García-Ca?averas, J.C., Donato, M.T., Castell, J.V., et al. Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method J. Lipid Res. 53(10),2231-2241(2012).